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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
Zhu Y, Prata LGPL, Gerdes EOW, Netto JME, Pirtskhalava T, Giorgadze N, Tripathi U, Inman CL, Johnson KO, Xue A, Palmer AK, Chen T, Schaefer K, Justice JN, Nambiar AM, Musi N, Kritchevsky SB, Chen J, Khosla S, Jurk D, Schafer MJ, Tchkonia T, Kirkland JL. Zhu Y, et al. Among authors: kritchevsky sb. EBioMedicine. 2022 Mar;77:103912. doi: 10.1016/j.ebiom.2022.103912. Epub 2022 Mar 13. EBioMedicine. 2022. PMID: 35292270 Free PMC article.
Corrigendum to: Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging.
Hadley EC, Kuchel GA, Newman AB, Allore HG, Bartley JM, Bergeman CS, Blinov ML, Colon-Emeric CS, Dabhar FS, Dugan LL, Dutta C, Eldadah BA, Ferrucci L, Kirkland JL, Kritchevsky SB, Lipsitz LA, Nadkarni NK, Reed MJ, Schmader KE, Sierra F, Studenski SA, Varadhan R, Walston JD, Whitson HE, Yung R. Hadley EC, et al. Among authors: kritchevsky sb. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):995. doi: 10.1093/gerona/glx172. J Gerontol A Biol Sci Med Sci. 2018. PMID: 29788088 Free PMC article. No abstract available.
A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.
Justice JN, Ferrucci L, Newman AB, Aroda VR, Bahnson JL, Divers J, Espeland MA, Marcovina S, Pollak MN, Kritchevsky SB, Barzilai N, Kuchel GA. Justice JN, et al. Among authors: kritchevsky sb. Geroscience. 2018 Dec;40(5-6):419-436. doi: 10.1007/s11357-018-0042-y. Epub 2018 Aug 27. Geroscience. 2018. PMID: 30151729 Free PMC article. Review.
Development of Clinical Trials to Extend Healthy Lifespan.
Justice JN, Niedernhofer L, Robbins PD, Aroda VR, Espeland MA, Kritchevsky SB, Kuchel GA, Barzilai N. Justice JN, et al. Among authors: kritchevsky sb. Cardiovasc Endocrinol Metab. 2018 Dec;7(4):80-83. doi: 10.1097/XCE.0000000000000159. Cardiovasc Endocrinol Metab. 2018. PMID: 30906924 Free PMC article.
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.
Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, Murabito JM, Ben-Shlomo Y, Espeland MA, Kirkland J, Melzer D, Ferrucci L. Newman AB, et al. Among authors: kritchevsky sb. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):77-86. doi: 10.1093/gerona/glz230. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31722007 Free PMC article. Review.
Testing the Geroscience Hypothesis: Early Days.
Kritchevsky SB, Justice JN. Kritchevsky SB, et al. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):99-101. doi: 10.1093/gerona/glz267. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31834386 Free PMC article. No abstract available.
Metformin Reduces Aging-Related Leaky Gut and Improves Cognitive Function by Beneficially Modulating Gut Microbiome/Goblet Cell/Mucin Axis.
Ahmadi S, Razazan A, Nagpal R, Jain S, Wang B, Mishra SP, Wang S, Justice J, Ding J, McClain DA, Kritchevsky SB, Kitzman D, Yadav H. Ahmadi S, et al. Among authors: kritchevsky sb. J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):e9-e21. doi: 10.1093/gerona/glaa056. J Gerontol A Biol Sci Med Sci. 2020. PMID: 32129462 Free PMC article.
617 results