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YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics.
Fan PD, Narzisi G, Jayaprakash AD, Venturini E, Robine N, Smibert P, Germer S, Yu HA, Jordan EJ, Paik PK, Janjigian YY, Chaft JE, Wang L, Jungbluth AA, Middha S, Spraggon L, Qiao H, Lovly CM, Kris MG, Riely GJ, Politi K, Varmus H, Ladanyi M. Fan PD, et al. Among authors: kris mg. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6030-E6038. doi: 10.1073/pnas.1717782115. Epub 2018 Jun 6. Proc Natl Acad Sci U S A. 2018. PMID: 29875142 Free PMC article.
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. Pao W, et al. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi: 10.1073/pnas.0405220101. Epub 2004 Aug 25. Proc Natl Acad Sci U S A. 2004. PMID: 15329413 Free PMC article.
EGFR mutations in small-cell lung cancers in patients who have never smoked.
Zakowski MF, Ladanyi M, Kris MG; Memorial Sloan-Kettering Cancer Center Lung Cancer OncoGenome Group. Zakowski MF, et al. Among authors: kris mg. N Engl J Med. 2006 Jul 13;355(2):213-5. doi: 10.1056/NEJMc053610. N Engl J Med. 2006. PMID: 16837691 No abstract available.
Molecular on/off switch.
Milton DT, Riely GJ, Pao W, Miller VA, Kris MG, Heelan RT. Milton DT, et al. Among authors: kris mg. J Clin Oncol. 2006 Oct 20;24(30):4940-2. doi: 10.1200/JCO.2006.06.4410. J Clin Oncol. 2006. PMID: 17050880 No abstract available.
519 results