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An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors.
Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, Klein O, Kuna K, Ouchan Y, Wöll S, Christ E, Weber D, Suchan M, Bukur T, Birtel M, Jahndel V, Mroz K, Hobohm K, Kranz L, Diken M, Kühlcke K, Türeci Ö, Sahin U. Reinhard K, et al. Among authors: kranz l. Science. 2020 Jan 24;367(6476):446-453. doi: 10.1126/science.aay5967. Epub 2020 Jan 2. Science. 2020. PMID: 31896660
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis.
Krienke C, Kolb L, Diken E, Streuber M, Kirchhoff S, Bukur T, Akilli-Öztürk Ö, Kranz LM, Berger H, Petschenka J, Diken M, Kreiter S, Yogev N, Waisman A, Karikó K, Türeci Ö, Sahin U. Krienke C, et al. Among authors: kranz lm. Science. 2021 Jan 8;371(6525):145-153. doi: 10.1126/science.aay3638. Science. 2021. PMID: 33414215
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy.
Kranz LM, Diken M, Haas H, Kreiter S, Loquai C, Reuter KC, Meng M, Fritz D, Vascotto F, Hefesha H, Grunwitz C, Vormehr M, Hüsemann Y, Selmi A, Kuhn AN, Buck J, Derhovanessian E, Rae R, Attig S, Diekmann J, Jabulowsky RA, Heesch S, Hassel J, Langguth P, Grabbe S, Huber C, Türeci Ö, Sahin U. Kranz LM, et al. Nature. 2016 Jun 16;534(7607):396-401. doi: 10.1038/nature18300. Epub 2016 Jun 1. Nature. 2016. PMID: 27281205
mRNA: A Versatile Molecule for Cancer Vaccines.
Diken M, Kranz LM, Kreiter S, Sahin U. Diken M, et al. Curr Issues Mol Biol. 2017;22:113-128. doi: 10.21775/cimb.022.113. Epub 2016 Nov 1. Curr Issues Mol Biol. 2017. PMID: 27801664 Free article. Review.
An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
Sahin U, Oehm P, Derhovanessian E, Jabulowsky RA, Vormehr M, Gold M, Maurus D, Schwarck-Kokarakis D, Kuhn AN, Omokoko T, Kranz LM, Diken M, Kreiter S, Haas H, Attig S, Rae R, Cuk K, Kemmer-Brück A, Breitkreuz A, Tolliver C, Caspar J, Quinkhardt J, Hebich L, Stein M, Hohberger A, Vogler I, Liebig I, Renken S, Sikorski J, Leierer M, Müller V, Mitzel-Rink H, Miederer M, Huber C, Grabbe S, Utikal J, Pinter A, Kaufmann R, Hassel JC, Loquai C, Türeci Ö. Sahin U, et al. Among authors: kranz lm. Nature. 2020 Sep;585(7823):107-112. doi: 10.1038/s41586-020-2537-9. Epub 2020 Jul 29. Nature. 2020. PMID: 32728218 Clinical Trial.
mRNA therapeutics in cancer immunotherapy.
Beck JD, Reidenbach D, Salomon N, Sahin U, Türeci Ö, Vormehr M, Kranz LM. Beck JD, et al. Mol Cancer. 2021 Apr 15;20(1):69. doi: 10.1186/s12943-021-01348-0. Mol Cancer. 2021. PMID: 33858437 Free PMC article. Review.
CIMT 2015: The right patient for the right therapy - Report on the 13th annual meeting of the Association for Cancer Immunotherapy.
Kranz LM, Birtel M, Krienke C, Grunwitz C, Petschenka J, Reuter KC, van de Roemer N, Vascotto F, Vormehr M, Kreiter S, Diken M. Kranz LM, et al. Hum Vaccin Immunother. 2016;12(1):213-21. doi: 10.1080/21645515.2015.1068485. Epub 2015 Jul 17. Hum Vaccin Immunother. 2016. PMID: 26186022 Free PMC article. No abstract available.
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer.
Vormehr M, Lehar S, Kranz LM, Tahtinen S, Oei Y, Javinal V, Delamarre L, Walzer KC, Diken M, Kreiter S, Mellman I, Sahin U, Schartner JM, Türeci Ö. Vormehr M, et al. Among authors: kranz lm. Oncoimmunology. 2020 May 13;9(1):1758004. doi: 10.1080/2162402X.2020.1758004. Oncoimmunology. 2020. PMID: 32923115 Free PMC article.
CIMT 2016: Mechanisms of efficacy in cancer immunotherapy - Report on the 14th Annual Meeting of the Association for Cancer Immunotherapy May 10-12 2016, Mainz, Germany.
Kranz LM, Birtel M, Hilscher L, Grunwitz C, Petschenka J, Vascotto F, Vormehr M, Voss RH, Kreiter S, Diken M. Kranz LM, et al. Hum Vaccin Immunother. 2016 Nov;12(11):2805-2812. doi: 10.1080/21645515.2016.1206677. Epub 2016 Jul 19. Hum Vaccin Immunother. 2016. PMID: 27435168 Free PMC article. No abstract available.
46 results