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The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.
Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A, Walz G, Piontek KB, Germino GG, Weimbs T. Shillingford JM, et al. Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. doi: 10.1073/pnas.0509694103. Epub 2006 Mar 27. Proc Natl Acad Sci U S A. 2006. PMID: 16567633 Free PMC article.
Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2.
Kuehn EW, Hirt MN, John AK, Muehlenhardt P, Boehlke C, Pütz M, Kramer-Zucker AG, Bashkurov M, van de Weyer PS, Kotsis F, Walz G. Kuehn EW, et al. Among authors: kramer zucker ag. Biochem Biophys Res Commun. 2007 Dec 28;364(4):861-6. doi: 10.1016/j.bbrc.2007.10.103. Epub 2007 Oct 26. Biochem Biophys Res Commun. 2007. PMID: 18273441
The subcellular localization of TRPP2 modulates its function.
Fu X, Wang Y, Schetle N, Gao H, Pütz M, von Gersdorff G, Walz G, Kramer-Zucker AG. Fu X, et al. Among authors: kramer zucker ag. J Am Soc Nephrol. 2008 Jul;19(7):1342-51. doi: 10.1681/ASN.2007070730. Epub 2008 Apr 16. J Am Soc Nephrol. 2008. PMID: 18417723 Free PMC article.
TRPP2 and TRPV4 form a polymodal sensory channel complex.
Köttgen M, Buchholz B, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, Walz G. Köttgen M, et al. J Cell Biol. 2008 Aug 11;182(3):437-47. doi: 10.1083/jcb.200805124. J Cell Biol. 2008. PMID: 18695040 Free PMC article.
Genetic and physical interaction between the NPHP5 and NPHP6 gene products.
Schäfer T, Pütz M, Lienkamp S, Ganner A, Bergbreiter A, Ramachandran H, Gieloff V, Gerner M, Mattonet C, Czarnecki PG, Sayer JA, Otto EA, Hildebrandt F, Kramer-Zucker A, Walz G. Schäfer T, et al. Hum Mol Genet. 2008 Dec 1;17(23):3655-62. doi: 10.1093/hmg/ddn260. Epub 2008 Aug 23. Hum Mol Genet. 2008. PMID: 18723859 Free PMC article.
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.
Skouloudaki K, Puetz M, Simons M, Courbard JR, Boehlke C, Hartleben B, Engel C, Moeller MJ, Englert C, Bollig F, Schäfer T, Ramachandran H, Mlodzik M, Huber TB, Kuehn EW, Kim E, Kramer-Zucker A, Walz G. Skouloudaki K, et al. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8579-84. doi: 10.1073/pnas.0811691106. Epub 2009 May 13. Proc Natl Acad Sci U S A. 2009. PMID: 19439659 Free PMC article.
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