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Safer chemicals using less animals: kick-off of the European ONTOX project.
Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH. Vinken M, et al. Among authors: kramer n. Toxicology. 2021 Jun 30;458:152846. doi: 10.1016/j.tox.2021.152846. Epub 2021 Jun 30. Toxicology. 2021. PMID: 34216698 Free article. Review.
PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop.
Bessems JG, Loizou G, Krishnan K, Clewell HJ 3rd, Bernasconi C, Bois F, Coecke S, Collnot EM, Diembeck W, Farcal LR, Geraets L, Gundert-Remy U, Kramer N, Küsters G, Leite SB, Pelkonen OR, Schröder K, Testai E, Wilk-Zasadna I, Zaldívar-Comenges JM. Bessems JG, et al. Among authors: kramer n. Regul Toxicol Pharmacol. 2014 Feb;68(1):119-39. doi: 10.1016/j.yrtph.2013.11.008. Epub 2013 Nov 26. Regul Toxicol Pharmacol. 2014. PMID: 24287156
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Beilmann M, et al. ALTEX. 2019;36(2):289-313. doi: 10.14573/altex.1808181. Epub 2018 Dec 20. ALTEX. 2019. PMID: 30570669 Free article.
Investigating combined toxicity of binary mixtures in bees: Meta-analysis of laboratory tests, modelling, mechanistic basis and implications for risk assessment.
Carnesecchi E, Svendsen C, Lasagni S, Grech A, Quignot N, Amzal B, Toma C, Tosi S, Rortais A, Cortinas-Abrahantes J, Capri E, Kramer N, Benfenati E, Spurgeon D, Guillot G, Dorne JLCM. Carnesecchi E, et al. Among authors: kramer n. Environ Int. 2019 Dec;133(Pt B):105256. doi: 10.1016/j.envint.2019.105256. Epub 2019 Nov 1. Environ Int. 2019. PMID: 31683157 Free article.
The use of adverse outcome pathways in the safety evaluation of food additives.
Vinken M, Kramer N, Allen TEH, Hoffmans Y, Thatcher N, Levorato S, Traussnig H, Schulte S, Boobis A, Thiel A, Rietjens IMCM. Vinken M, et al. Among authors: kramer n. Arch Toxicol. 2020 Mar;94(3):959-966. doi: 10.1007/s00204-020-02670-0. Epub 2020 Feb 17. Arch Toxicol. 2020. PMID: 32065296
Integrating QSAR models predicting acute contact toxicity and mode of action profiling in honey bees (A. mellifera): Data curation using open source databases, performance testing and validation.
Carnesecchi E, Toma C, Roncaglioni A, Kramer N, Benfenati E, Dorne JLCM. Carnesecchi E, et al. Among authors: kramer n. Sci Total Environ. 2020 Sep 15;735:139243. doi: 10.1016/j.scitotenv.2020.139243. Epub 2020 May 17. Sci Total Environ. 2020. PMID: 32480144 Free article.
New approach methodologies (NAMs) for human-relevant biokinetics predictions. Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.
Punt A, Bouwmeester H, Blaauboer BJ, Coecke S, Hakkert B, Hendriks DFG, Jennings P, Kramer NI, Neuhoff S, Masereeuw R, Paini A, Peijnenburg AACM, Rooseboom M, Shuler ML, Sorrell I, Spee B, Strikwold M, Van der Meer AD, Van der Zande M, Vinken M, Yang H, Bos PMJ, Heringa MB. Punt A, et al. ALTEX. 2020;37(4):607-622. doi: 10.14573/altex.2003242. Epub 2020 Jun 8. ALTEX. 2020. PMID: 32521035 Free article.
629 results