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The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.
Kari V, Raul SK, Henck JM, Kitz J, Kramer F, Kosinsky RL, Übelmesser N, Mansour WY, Eggert J, Spitzner M, Najafova Z, Bastians H, Grade M, Gaedcke J, Wegwitz F, Johnsen SA. Kari V, et al. Among authors: kramer f. Clin Epigenetics. 2019 Jan 7;11(1):4. doi: 10.1186/s13148-018-0601-1. Clin Epigenetics. 2019. PMID: 30616689 Free PMC article.
A gene expression signature for chemoradiosensitivity of colorectal cancer cells.
Spitzner M, Emons G, Kramer F, Gaedcke J, Rave-Fränk M, Scharf JG, Burfeind P, Becker H, Beissbarth T, Ghadimi BM, Ried T, Grade M. Spitzner M, et al. Among authors: kramer f. Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1184-92. doi: 10.1016/j.ijrobp.2010.06.023. Int J Radiat Oncol Biol Phys. 2010. PMID: 20970032 Free PMC article.
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.
Kendziorra E, Ahlborn K, Spitzner M, Rave-Fränk M, Emons G, Gaedcke J, Kramer F, Wolff HA, Becker H, Beissbarth T, Ebner R, Ghadimi BM, Pukrop T, Ried T, Grade M. Kendziorra E, et al. Among authors: kramer f. Carcinogenesis. 2011 Dec;32(12):1824-31. doi: 10.1093/carcin/bgr222. Epub 2011 Oct 8. Carcinogenesis. 2011. PMID: 21983179 Free PMC article.
Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ. Hummon AB, et al. Among authors: kramer f. Mol Cancer. 2012 Jan 4;11:1. doi: 10.1186/1476-4598-11-1. Mol Cancer. 2012. PMID: 22216762 Free PMC article.
Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g.
Salendo J, Spitzner M, Kramer F, Zhang X, Jo P, Wolff HA, Kitz J, Kaulfuß S, Beißbarth T, Dobbelstein M, Ghadimi M, Grade M, Gaedcke J. Salendo J, et al. Among authors: kramer f. Radiother Oncol. 2013 Sep;108(3):451-7. doi: 10.1016/j.radonc.2013.06.032. Epub 2013 Aug 7. Radiother Oncol. 2013. PMID: 23932154
STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.
Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M. Spitzner M, et al. Among authors: kramer f. Int J Cancer. 2014 Feb 15;134(4):997-1007. doi: 10.1002/ijc.28429. Epub 2013 Sep 3. Int J Cancer. 2014. PMID: 23934972 Free PMC article.
493 results