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Conjugation of a 5-nitrofuran-2-oyl moiety to aminoalkylimidazoles produces non-toxic nitrofurans that are efficacious in vitro and in vivo against multidrug-resistant Mycobacterium tuberculosis.
Krasavin M, Lukin A, Vedekhina T, Manicheva O, Dogonadze M, Vinogradova T, Zabolotnykh N, Rogacheva E, Kraeva L, Yablonsky P. Krasavin M, et al. Eur J Med Chem. 2018 Sep 5;157:1115-1126. doi: 10.1016/j.ejmech.2018.08.068. Epub 2018 Aug 29. Eur J Med Chem. 2018. PMID: 30179748
Attachment of a 5-nitrofuroyl moiety to spirocyclic piperidines produces non-toxic nitrofurans that are efficacious in vitro against multidrug-resistant Mycobacterium tuberculosis.
Krasavin M, Lukin A, Vedekhina T, Manicheva O, Dogonadze M, Vinogradova T, Zabolotnykh N, Rogacheva E, Kraeva L, Sharoyko V, Tennikova TB, Dar'in D, Sokolovich E. Krasavin M, et al. Eur J Med Chem. 2019 Mar 15;166:125-135. doi: 10.1016/j.ejmech.2019.01.050. Epub 2019 Jan 23. Eur J Med Chem. 2019. PMID: 30703656
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