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Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma.
Gleason CE, Dickson MA, Klein Dooley ME, Antonescu CR, Gularte-Mérida R, Benitez M, Delgado JI, Kataru RP, Tan MWY, Bradic M, Adamson TE, Seier K, Richards AL, Palafox M, Chan E, D'Angelo SP, Gounder MM, Keohan ML, Kelly CM, Chi P, Movva S, Landa J, Crago AM, Donoghue MTA, Qin LX, Serra V, Turkekul M, Barlas A, Firester DM, Manova-Todorova K, Mehrara BJ, Kovatcheva M, Tan NS, Singer S, Tap WD, Koff A. Gleason CE, et al. Among authors: kovatcheva m. Clin Cancer Res. 2024 Feb 16;30(4):703-718. doi: 10.1158/1078-0432.CCR-23-2378. Clin Cancer Res. 2024. PMID: 37695642 Free PMC article.
ATRX is a regulator of therapy induced senescence in human cells.
Kovatcheva M, Liao W, Klein ME, Robine N, Geiger H, Crago AM, Dickson MA, Tap WD, Singer S, Koff A. Kovatcheva M, et al. Nat Commun. 2017 Aug 30;8(1):386. doi: 10.1038/s41467-017-00540-5. Nat Commun. 2017. PMID: 28855512 Free PMC article.
Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity.
Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, Ruano I, Attolini CS, Prats N, López-Domínguez JA, Kovatcheva M, Garralda E, Muñoz J, Caron E, Abad M, Gros A, Pietrocola F, Serrano M. Marin I, et al. Among authors: kovatcheva m. Cancer Discov. 2023 Feb 6;13(2):410-431. doi: 10.1158/2159-8290.CD-22-0523. Cancer Discov. 2023. PMID: 36302218 Free PMC article.
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair.
Kovatcheva M, Melendez E, Chondronasiou D, Pietrocola F, Bernad R, Caballe A, Junza A, Capellades J, Holguín-Horcajo A, Prats N, Durand S, Rovira M, Yanes O, Stephan-Otto Attolini C, Kroemer G, Serrano M. Kovatcheva M, et al. Nat Metab. 2023 Nov;5(11):1911-1930. doi: 10.1038/s42255-023-00916-6. Epub 2023 Nov 16. Nat Metab. 2023. PMID: 37973897 Free PMC article.
Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice.
Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, Ros E, Estruch R, Serrano M, Lamuela-Raventós RM. Domínguez-López I, et al. Among authors: kovatcheva m. J Sci Food Agric. 2024 Jan 30;104(2):875-882. doi: 10.1002/jsfa.12976. Epub 2023 Sep 19. J Sci Food Agric. 2024. PMID: 37690097 Free article.
Deciphering the roadmap of in vivo reprogramming toward pluripotency.
Chondronasiou D, Martínez de Villarreal J, Melendez E, Lynch CJ, Pozo ND, Kovatcheva M, Aguilera M, Prats N, Real FX, Serrano M. Chondronasiou D, et al. Among authors: kovatcheva m. Stem Cell Reports. 2022 Nov 8;17(11):2501-2517. doi: 10.1016/j.stemcr.2022.09.009. Epub 2022 Oct 20. Stem Cell Reports. 2022. PMID: 36270281 Free PMC article.