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Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells.
Sandoval JA, Tomilov A, Datta S, Allen S, O'Donnell R, Sears T, Woolard K, Kovalskyy D, Angelastro JM, Cortopassi G. Sandoval JA, et al. Among authors: kovalskyy d. Pharmaceuticals (Basel). 2020 Nov 24;13(12):419. doi: 10.3390/ph13120419. Pharmaceuticals (Basel). 2020. PMID: 33255358 Free PMC article.
Targeting Tat-TAR RNA Interaction for HIV-1 Inhibition.
Alanazi A, Ivanov A, Kumari N, Lin X, Wang S, Kovalskyy D, Nekhai S. Alanazi A, et al. Among authors: kovalskyy d. Viruses. 2021 Oct 6;13(10):2004. doi: 10.3390/v13102004. Viruses. 2021. PMID: 34696435 Free PMC article.
The small-molecule 3G11 inhibits HIV-1 reverse transcription.
Opp S, Fricke T, Shepard C, Kovalskyy D, Bhattacharya A, Herkules F, Ivanov DN, Kim B, Valle-Casuso J, Diaz-Griffero F. Opp S, et al. Among authors: kovalskyy d. Chem Biol Drug Des. 2017 Apr;89(4):608-618. doi: 10.1111/cbdd.12886. Epub 2016 Nov 15. Chem Biol Drug Des. 2017. PMID: 27748043 Free PMC article.
Phenyl-1-Pyridin-2yl-ethanone-based iron chelators increase IκB-α expression, modulate CDK2 and CDK9 activities, and inhibit HIV-1 transcription.
Kumari N, Iordanskiy S, Kovalskyy D, Breuer D, Niu X, Lin X, Xu M, Gavrilenko K, Kashanchi F, Dhawan S, Nekhai S. Kumari N, et al. Among authors: kovalskyy d. Antimicrob Agents Chemother. 2014 Nov;58(11):6558-71. doi: 10.1128/AAC.02918-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155598 Free PMC article.
Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.
Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S. Tyagi M, et al. Among authors: kovalskyy d. Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4. Retrovirology. 2015. PMID: 26178009 Free PMC article.
Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.
Ilinykh PA, Tigabu B, Ivanov A, Ammosova T, Obukhov Y, Garron T, Kumari N, Kovalskyy D, Platonov MO, Naumchik VS, Freiberg AN, Nekhai S, Bukreyev A. Ilinykh PA, et al. Among authors: kovalskyy d. J Biol Chem. 2014 Aug 15;289(33):22723-22738. doi: 10.1074/jbc.M114.575050. Epub 2014 Jun 16. J Biol Chem. 2014. PMID: 24936058 Free PMC article.
Effect of mimetic CDK9 inhibitors on HIV-1-activated transcription.
Van Duyne R, Guendel I, Jaworski E, Sampey G, Klase Z, Chen H, Zeng C, Kovalskyy D, El Kouni MH, Lepene B, Patanarut A, Nekhai S, Price DH, Kashanchi F. Van Duyne R, et al. Among authors: kovalskyy d. J Mol Biol. 2013 Feb 22;425(4):812-29. doi: 10.1016/j.jmb.2012.12.005. Epub 2012 Dec 13. J Mol Biol. 2013. PMID: 23247501 Free PMC article.
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