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Symmetric dimeric bisbenzimidazoles DBP(n) reduce methylation of RARB and PTEN while significantly increase methylation of rRNA genes in MCF-7 cancer cells.
Kostyuk SV, Kvasha MA, Khrabrova DA, Kirsanova OV, Ershova ES, Malinovskaya EM, Veiko NN, Ivanov AA, Koval VS, Zhuze AL, Tashlitsky VH, Umriukhin PE, Kutsev SI, Gromova ES. Kostyuk SV, et al. Among authors: koval vs. PLoS One. 2018 Jan 12;13(1):e0189826. doi: 10.1371/journal.pone.0189826. eCollection 2018. PLoS One. 2018. PMID: 29329300 Free PMC article.
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).
Koval VS, Arutyunyan AF, Salyanov VI, Kostyukov AA, Melkina OE, Zavilgelsky GB, Klimova RR, Kushch AA, Korolev SP, Agapkina YY, Gottikh MB, Vaiman AV, Rybalkina EY, Susova OY, Zhuze AL. Koval VS, et al. Bioorg Med Chem. 2020 Apr 1;28(7):115378. doi: 10.1016/j.bmc.2020.115378. Epub 2020 Feb 13. Bioorg Med Chem. 2020. PMID: 32089391
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