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Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases.
Wu M, Vadlakonda S, El-Kattan Y, Ghosh A, Lin TH, Chambers-Wilson R, Cheng X, Bantia S, Kellogg-Yelder D, Chand P, Babu YS, Kotian PL. Wu M, et al. Among authors: kotian pl. Eur J Med Chem. 2024 Jan 15;264:115991. doi: 10.1016/j.ejmech.2023.115991. Epub 2023 Nov 29. Eur J Med Chem. 2024. PMID: 38118393
Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
Kotian PL, Wu M, Vadlakonda S, Chintareddy V, Lu P, Juarez L, Kellogg-Yelder D, Chen X, Muppa S, Chambers-Wilson R, Davis Parker C, Williams J, Polach KJ, Zhang W, Raman K, Babu YS. Kotian PL, et al. J Med Chem. 2021 Sep 9;64(17):12453-12468. doi: 10.1021/acs.jmedchem.1c00511. Epub 2021 Aug 26. J Med Chem. 2021. PMID: 34436898
BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
Taylor R, Kotian P, Warren T, Panchal R, Bavari S, Julander J, Dobo S, Rose A, El-Kattan Y, Taubenheim B, Babu Y, Sheridan WP. Taylor R, et al. Among authors: kotian p. J Infect Public Health. 2016 May-Jun;9(3):220-6. doi: 10.1016/j.jiph.2016.04.002. Epub 2016 Apr 16. J Infect Public Health. 2016. PMID: 27095300 Free PMC article. Review.
34 results