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Page 1
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. Among authors: kotake t. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. Among authors: kotake t. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist.
Nishimura Y, Esaki T, Isshiki Y, Furuta Y, Mizutani A, Kotake T, Emura T, Watanabe Y, Ohta M, Nakagawa T, Ogawa K, Arai S, Noda H, Kitamura H, Shimizu M, Tamura T, Sato H. Nishimura Y, et al. Among authors: kotake t. J Med Chem. 2020 May 28;63(10):5089-5099. doi: 10.1021/acs.jmedchem.9b01743. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32022560
Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism.
Nishimura Y, Esaki T, Isshiki Y, Okamoto N, Furuta Y, Kotake T, Watanabe Y, Ohta M, Nakagawa T, Noda H, Shimizu M, Saito H, Tamura T, Sato H. Nishimura Y, et al. Among authors: kotake t. J Med Chem. 2018 Jul 26;61(14):5949-5962. doi: 10.1021/acs.jmedchem.8b00182. Epub 2018 Jul 3. J Med Chem. 2018. PMID: 29932656
Comparison of cisplatin-based versus standard preoperative chemotherapy in patients with operable triple-negative breast cancer: propensity score matching and inverse probability of treatment weighting analysis.
Yamaguchi A, Kawaguchi K, Kawanishi K, Maeshima Y, Nakakura A, Kataoka TR, Takahara S, Nakagawa S, Yonezawa A, Takada M, Kawashima M, Kawaguchi-Sakita N, Kotake T, Suzuki E, Shimizu H, Torii M, Morita S, Ishiguro H, Toi M. Yamaguchi A, et al. Among authors: kotake t. Breast Cancer Res Treat. 2024 Apr;204(2):261-275. doi: 10.1007/s10549-023-07163-z. Epub 2023 Dec 21. Breast Cancer Res Treat. 2024. PMID: 38123790 Free PMC article.
Association between National Institutes of Health Stroke Scale and Functional Independence Measure scores in patients with ischemic stroke from convalescent rehabilitation outcomes.
Senda J, Ito K, Kotake T, Mizuno M, Kishimoto H, Yasui K, Nakagawa-Senda H, Katsuno M, Nishida Y, Sobue G. Senda J, et al. Among authors: kotake t. Nagoya J Med Sci. 2023 Aug;85(3):428-443. doi: 10.18999/nagjms.85.3.428. Nagoya J Med Sci. 2023. PMID: 37829489 Free PMC article.
Integrated genome-wide differentiation and association analyses identify causal genes underlying breeding-selected grain quality traits in japonica rice.
Yoshida H, Okada S, Wang F, Shiota S, Mori M, Kawamura M, Zhao X, Wang Y, Nishigaki N, Kobayashi A, Miura K, Yoshida S, Ikegami M, Ito A, Huang LT, Caroline Hsing YI, Yamagata Y, Morinaka Y, Yamasaki M, Kotake T, Yamamoto E, Sun J, Hirano K, Matsuoka M. Yoshida H, et al. Among authors: kotake t. Mol Plant. 2023 Sep 4;16(9):1460-1477. doi: 10.1016/j.molp.2023.09.002. Epub 2023 Sep 9. Mol Plant. 2023. PMID: 37674315
462 results