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Page 1
Synthesis of the Major Mammalian Metabolites of THCV.
Tinto F, Villano R, Kostrzewa M, Ligresti A, Straker H, Manzo E. Tinto F, et al. Among authors: kostrzewa m. J Nat Prod. 2020 Jul 24;83(7):2060-2065. doi: 10.1021/acs.jnatprod.9b00831. Epub 2020 Jul 10. J Nat Prod. 2020. PMID: 32649196
Modeling Acquired Resistance to the Second-Generation Androgen Receptor Antagonist Enzalutamide in the TRAMP Model of Prostate Cancer.
Cerasuolo M, Maccarinelli F, Coltrini D, Mahmoud AM, Marolda V, Ghedini GC, Rezzola S, Giacomini A, Triggiani L, Kostrzewa M, Verde R, Paris D, Melck D, Presta M, Ligresti A, Ronca R. Cerasuolo M, et al. Among authors: kostrzewa m. Cancer Res. 2020 Apr 1;80(7):1564-1577. doi: 10.1158/0008-5472.CAN-18-3637. Epub 2020 Feb 6. Cancer Res. 2020. PMID: 32029552
Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.
Mugnaini C, Kostrzewa M, Bryk M, Mahmoud AM, Brizzi A, Lamponi S, Giorgi G, Ferlenghi F, Vacondio F, Maccioni P, Colombo G, Mor M, Starowicz K, Di Marzo V, Ligresti A, Corelli F. Mugnaini C, et al. Among authors: kostrzewa m. J Med Chem. 2020 Jul 9;63(13):7369-7391. doi: 10.1021/acs.jmedchem.0c00595. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32515588
Synthesis and molecular targets of N-13-hydroxy-octadienoyl-ethanolamine, a novel endogenous bioactive 15-lipoxygenase-derived metabolite of N-linoleoyl-ethanolamine found in the skin and saliva.
Tinto F, Archambault AS, Dumais É, Rakotoarivelo V, Kostrzewa M, Martin C, Plante PL, Desjardins Y, Simard M, Pouliot R, De Petrocellis L, Ligresti A, Di Marzo V, Flamand N. Tinto F, et al. Among authors: kostrzewa m. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158954. doi: 10.1016/j.bbalip.2021.158954. Epub 2021 Apr 27. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 33915294
New Coumarin Derivatives as Cholinergic and Cannabinoid System Modulators.
Montanari S, Allarà M, Scalvini L, Kostrzewa M, Belluti F, Gobbi S, Naldi M, Rivara S, Bartolini M, Ligresti A, Bisi A, Rampa A. Montanari S, et al. Among authors: kostrzewa m. Molecules. 2021 May 28;26(11):3254. doi: 10.3390/molecules26113254. Molecules. 2021. PMID: 34071439 Free PMC article.
Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.
Archambault AS, Tinto F, Dumais É, Rakotoarivelo V, Kostrzewa M, Plante PL, Martin C, Simard M, Silvestri C, Pouliot R, Laviolette M, Boulet LP, Vitale RM, Ligresti A, Di Marzo V, Flamand N. Archambault AS, et al. Among authors: kostrzewa m. Cells. 2021 Sep 5;10(9):2322. doi: 10.3390/cells10092322. Cells. 2021. PMID: 34571971 Free PMC article.
N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Gianquinto E, Sodano F, Rolando B, Kostrzewa M, Allarà M, Mahmoud AM, Kumar P, Spyrakis F, Ligresti A, Chegaev K. Gianquinto E, et al. Among authors: kostrzewa m. Molecules. 2022 Nov 23;27(23):8152. doi: 10.3390/molecules27238152. Molecules. 2022. PMID: 36500256 Free PMC article.
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase.
Intranuovo F, Brunetti L, DelRe P, Mangiatordi GF, Stefanachi A, Laghezza A, Niso M, Leonetti F, Loiodice F, Ligresti A, Kostrzewa M, Brea J, Loza MI, Sotelo E, Saviano M, Colabufo NA, Riganti C, Abate C, Contino M. Intranuovo F, et al. Among authors: kostrzewa m. J Med Chem. 2023 Jan 12;66(1):235-250. doi: 10.1021/acs.jmedchem.2c01084. Epub 2022 Dec 21. J Med Chem. 2023. PMID: 36542836
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R).
Graziano G, Delre P, Carofiglio F, Brea J, Ligresti A, Kostrzewa M, Riganti C, Gioè-Gallo C, Majellaro M, Nicolotti O, Colabufo NA, Abate C, Loza MI, Sotelo E, Mangiatordi GF, Contino M, Stefanachi A, Leonetti F. Graziano G, et al. Among authors: kostrzewa m. Eur J Med Chem. 2023 Feb 15;248:115109. doi: 10.1016/j.ejmech.2023.115109. Epub 2023 Jan 13. Eur J Med Chem. 2023. PMID: 36657299
257 results