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Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure.
Konings GF, Saarinen N, Delvoux B, Kooreman L, Koskimies P, Krakstad C, Fasmer KE, Haldorsen IS, Zaffagnini A, Häkkinen MR, Auriola S, Dubois L, Lieuwes N, Verhaegen F, Schyns LE, Kruitwagen RF; ENITEC Consortium; Xanthoulea S, Romano A. Konings GF, et al. Among authors: koskimies p. Int J Mol Sci. 2018 Aug 28;19(9):2547. doi: 10.3390/ijms19092547. Int J Mol Sci. 2018. PMID: 30154339 Free PMC article.
Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model.
Xanthoulea S, Konings GFJ, Saarinen N, Delvoux B, Kooreman LFS, Koskimies P, Häkkinen MR, Auriola S, D'Avanzo E, Walid Y, Verhaegen F, Lieuwes NG, Caiment F, Kruitwagen R; ENITEC; Romano A. Xanthoulea S, et al. Among authors: koskimies p. Cancer Lett. 2021 Jun 28;508:18-29. doi: 10.1016/j.canlet.2021.03.019. Epub 2021 Mar 21. Cancer Lett. 2021. PMID: 33762202 Free article.
Blocking 17β-hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach.
Konings GF, Cornel KM, Xanthoulea S, Delvoux B, Skowron MA, Kooreman L, Koskimies P, Krakstad C, Salvesen HB, van Kuijk K, Schrooders YJ, Vooijs M, Groot AJ, Bongers MY, Kruitwagen RF; ENITEC; Romano A. Konings GF, et al. Among authors: koskimies p. J Pathol. 2018 Feb;244(2):203-214. doi: 10.1002/path.5004. Epub 2018 Jan 3. J Pathol. 2018. PMID: 29144553
Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.
Konings G, Brentjens L, Delvoux B, Linnanen T, Cornel K, Koskimies P, Bongers M, Kruitwagen R, Xanthoulea S, Romano A. Konings G, et al. Among authors: koskimies p. Front Pharmacol. 2018 Sep 19;9:940. doi: 10.3389/fphar.2018.00940. eCollection 2018. Front Pharmacol. 2018. PMID: 30283331 Free PMC article. Review.
Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice.
Heinosalo T, Rytkönen KT, Saarinen N, Järvensivu P, Damdimopoulou P, Strauss L, Orasniemi S, Horshauge P, Gabriel M, Koskimies P, Ohlsson C, Kronqvist P, Poutanen M. Heinosalo T, et al. Among authors: koskimies p. Int J Mol Sci. 2022 Apr 27;23(9):4815. doi: 10.3390/ijms23094815. Int J Mol Sci. 2022. PMID: 35563206 Free PMC article.
Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice.
Saloniemi T, Järvensivu P, Koskimies P, Jokela H, Lamminen T, Ghaem-Maghami S, Dina R, Damdimopoulou P, Mäkelä S, Perheentupa A, Kujari H, Brosens J, Poutanen M. Saloniemi T, et al. Among authors: koskimies p. Am J Pathol. 2010 Mar;176(3):1443-51. doi: 10.2353/ajpath.2010.090325. Epub 2010 Jan 21. Am J Pathol. 2010. PMID: 20093485 Free PMC article.
30 results