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LRRK2 protects immune cells against erastin-induced ferroptosis.
Oun A, Soliman A, Trombetta-Lima M, Tzepapadaki A, Tsagkari D, Kortholt A, Dolga AM. Oun A, et al. Among authors: kortholt a. Neurobiol Dis. 2022 Dec;175:105917. doi: 10.1016/j.nbd.2022.105917. Epub 2022 Nov 3. Neurobiol Dis. 2022. PMID: 36336242 Free article.
Allosteric inhibition of LRRK2, where are we now.
Soliman A, Cankara FN, Kortholt A. Soliman A, et al. Among authors: kortholt a. Biochem Soc Trans. 2020 Oct 30;48(5):2185-2194. doi: 10.1042/BST20200424. Biochem Soc Trans. 2020. PMID: 33079169 Free PMC article. Review.
Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, Rideout H, Kortholt A, Kennedy EJ. Helton LG, et al. Among authors: kortholt a. ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8. ACS Chem Biol. 2021. PMID: 34496561 Free article.
Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, Steyaert J, Herberg FW, Kortholt A, Gloeckner CJ, Versées W. Singh RK, et al. Among authors: kortholt a. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2112712119. doi: 10.1073/pnas.2112712119. Proc Natl Acad Sci U S A. 2022. PMID: 35217606 Free PMC article.
73 results