Effects of Common Pesticides on Prostaglandin D2 (PGD2) Inhibition in SC5 Mouse Sertoli Cells, Evidence of Binding at the COX-2 Active Site, and Implications for Endocrine Disruption.
Kugathas S, Audouze K, Ermler S, Orton F, Rosivatz E, Scholze M, Kortenkamp A.
Kugathas S, et al. Among authors: kortenkamp a.
Environ Health Perspect. 2016 Apr;124(4):452-9. doi: 10.1289/ehp.1409544. Epub 2015 Sep 11.
Environ Health Perspect. 2016.
PMID: 26359731
Free PMC article.
CONCLUSIONS: Chemicals with structural features more varied than previously thought can suppress PGD2 synthesis. Our findings signal a need for in vivo studies to establish the extent of endocrine-disrupting effects that might arise from simultaneous interference with PGD2 …
CONCLUSIONS: Chemicals with structural features more varied than previously thought can suppress PGD2 synthesis. Our findings signal a …