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Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.
Kosztelnik M, Kurucz A, Papp D, Jones E, Sigmond T, Barna J, Traka MH, Lorincz T, Szarka A, Banhegyi G, Vellai T, Korcsmaros T, Kapuy O. Kosztelnik M, et al. Among authors: korcsmaros t. FASEB J. 2019 Feb;33(2):2372-2387. doi: 10.1096/fj.201800565RR. Epub 2018 Oct 2. FASEB J. 2019. PMID: 30277819 Free PMC article.
This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human morbidities characterized by oxidative stress, such as neurodegenerative diseases, certain cancer types, and in metabolic diseases.-Kosztelnik, …
This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human mor …
Network-based tools for the identification of novel drug targets.
Farkas IJ, Korcsmáros T, Kovács IA, Mihalik Á, Palotai R, Simkó GI, Szalay KZ, Szalay-Beko M, Vellai T, Wang S, Csermely P. Farkas IJ, et al. Among authors: korcsmaros t. Sci Signal. 2011 May 17;4(173):pt3. doi: 10.1126/scisignal.2001950. Sci Signal. 2011. PMID: 21586727
SignaLink 2 - a signaling pathway resource with multi-layered regulatory networks.
Fazekas D, Koltai M, Türei D, Módos D, Pálfy M, Dúl Z, Zsákai L, Szalay-Bekő M, Lenti K, Farkas IJ, Vellai T, Csermely P, Korcsmáros T. Fazekas D, et al. Among authors: korcsmaros t. BMC Syst Biol. 2013 Jan 18;7:7. doi: 10.1186/1752-0509-7-7. BMC Syst Biol. 2013. PMID: 23331499 Free PMC article.
105 results