Kooistra AJ - Search Results

1

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening.

de Heuvel E, Kooistra AJ, Edink E, van Klaveren S, Stuijt J, van der Meer T, Sadek P, Mabille D, Caljon G, Maes L, Siderius M, de Esch IJP, Sterk GJ, Leurs R. de Heuvel E, et al. Among authors: kooistra aj. Front Chem. 2021 Jan 21;8:608030. doi: 10.3389/fchem.2020.608030. eCollection 2020. Front Chem. 2021. PMID: 33553105 Free PMC article.

2

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Istyastono EP, Nijmeijer S, Lim HD, van de Stolpe A, Roumen L, Kooistra AJ, Vischer HF, de Esch IJ, Leurs R, de Graaf C. Istyastono EP, et al. Among authors: kooistra aj. J Med Chem. 2011 Dec 8;54(23):8136-47. doi: 10.1021/jm201042n. Epub 2011 Nov 7. J Med Chem. 2011. PMID: 22003888

3

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor.

de Graaf C, Kooistra AJ, Vischer HF, Katritch V, Kuijer M, Shiroishi M, Iwata S, Shimamura T, Stevens RC, de Esch IJ, Leurs R. de Graaf C, et al. Among authors: kooistra aj. J Med Chem. 2011 Dec 8;54(23):8195-206. doi: 10.1021/jm2011589. Epub 2011 Nov 7. J Med Chem. 2011. PMID: 22007643 Free PMC article.

4

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.

Akdemir A, Edink E, Thompson AJ, Lummis SC, Kooistra AJ, de Graaf C, de Esch IJ. Akdemir A, et al. Among authors: kooistra aj. Bioorg Med Chem. 2012 Oct 1;20(19):5992-6002. doi: 10.1016/j.bmc.2012.06.054. Epub 2012 Jul 11. Bioorg Med Chem. 2012. PMID: 22959526 Free PMC article.

5

Virtual fragment screening: discovery of histamine H3 receptor ligands using ligand-based and protein-based molecular fingerprints.

Sirci F, Istyastono EP, Vischer HF, Kooistra AJ, Nijmeijer S, Kuijer M, Wijtmans M, Mannhold R, Leurs R, de Esch IJ, de Graaf C. Sirci F, et al. Among authors: kooistra aj. J Chem Inf Model. 2012 Dec 21;52(12):3308-24. doi: 10.1021/ci3004094. Epub 2012 Dec 3. J Chem Inf Model. 2012. PMID: 23140085

6

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.

de Graaf C, Vischer HF, de Kloe GE, Kooistra AJ, Nijmeijer S, Kuijer M, Verheij MH, England PJ, van Muijlwijk-Koezen JE, Leurs R, de Esch IJ. de Graaf C, et al. Among authors: kooistra aj. Drug Discov Today. 2013 Apr;18(7-8):323-30. doi: 10.1016/j.drudis.2012.12.003. Epub 2012 Dec 22. Drug Discov Today. 2013. PMID: 23266367

7

From heptahelical bundle to hits from the Haystack: structure-based virtual screening for GPCR ligands.

Kooistra AJ, Roumen L, Leurs R, de Esch IJ, de Graaf C. Kooistra AJ, et al. Methods Enzymol. 2013;522:279-336. doi: 10.1016/B978-0-12-407865-9.00015-7. Methods Enzymol. 2013. PMID: 23374191 Review.

8

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R. Jansen C, et al. Among authors: kooistra aj. J Med Chem. 2013 Mar 14;56(5):2087-96. doi: 10.1021/jm3017877. Epub 2013 Mar 1. J Med Chem. 2013. PMID: 23409953 Free PMC article.

9

A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.

Kooistra AJ, Kuhne S, de Esch IJ, Leurs R, de Graaf C. Kooistra AJ, et al. Br J Pharmacol. 2013 Sep;170(1):101-26. doi: 10.1111/bph.12248. Br J Pharmacol. 2013. PMID: 23713847 Free PMC article.

10

KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

van Linden OP, Kooistra AJ, Leurs R, de Esch IJ, de Graaf C. van Linden OP, et al. Among authors: kooistra aj. J Med Chem. 2014 Jan 23;57(2):249-77. doi: 10.1021/jm400378w. Epub 2013 Sep 20. J Med Chem. 2014. PMID: 23941661

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