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Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor.
Deschaine SL, Hedegaard MA, Pince CL, Farokhnia M, Moose JE, Stock IA, Adusumalli S, Akhlaghi F, Hougland JL, Sulima A, Rice KC, Koob GF, Vendruscolo LF, Holst B, Leggio L. Deschaine SL, et al. Among authors: koob gf. J Pharmacol Exp Ther. 2023 Aug;386(2):117-128. doi: 10.1124/jpet.122.001393. Epub 2023 Jan 11. J Pharmacol Exp Ther. 2023. PMID: 36631279 Free PMC article.
Heroin- and Fentanyl-Induced Respiratory Depression in a Rat Plethysmography Model: Potency, Tolerance, and Sex Differences.
Marchette RCN, Carlson ER, Frye EV, Hastings LE, Vendruscolo JCM, Mejias-Torres G, Lewis SJ, Hampson A, Volkow ND, Vendruscolo LF, Koob GF. Marchette RCN, et al. Among authors: koob gf. J Pharmacol Exp Ther. 2023 May;385(2):117-134. doi: 10.1124/jpet.122.001476. Epub 2023 Feb 24. J Pharmacol Exp Ther. 2023. PMID: 36828628 Free PMC article.
Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet.
Leggio L, Leko A, Gregory-Flores A, Marchette R, Gomez J, Vendruscolo J, Repunte-Canonigo V, Chuong V, Deschaine S, Whiting K, Jackson S, Cornejo M, Perello M, You ZB, Eckhaus M, Janda K, Zorman B, Sumazin P, Koob G, Michaelides M, Sanna PP, Vendruscolo L. Leggio L, et al. Res Sq [Preprint]. 2023 Oct 18:rs.3.rs-3236045. doi: 10.21203/rs.3.rs-3236045/v1. Res Sq. 2023. PMID: 37886546 Free PMC article. Preprint.
810 results