Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS.
Perrot CY, Sawada J, Komatsu M.
Perrot CY, et al. Among authors: komatsu m.
FASEB J. 2018 May 18;32(11):fj201700818RRR. doi: 10.1096/fj.201700818RRR. Online ahead of print.
FASEB J. 2018.
PMID: 29775418
Free PMC article.
Our study demonstrated that, contrary to the widely accepted notion, cAMP elevation in endothelial cells ultimately increases vascular permeability, and the cAMP-dependent RRAS repression critically contributes to this effect.-Perrot, C. Y., Sawada, J., Komatsu, M. …
Our study demonstrated that, contrary to the widely accepted notion, cAMP elevation in endothelial cells ultimately increases vascular perme …