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Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice.
Akhmetshina A, Bianco V, Bradić I, Korbelius M, Pirchheim A, Kuentzel KB, Eichmann TO, Hinteregger H, Kolb D, Habisch H, Liesinger L, Madl T, Sattler W, Radović B, Sedej S, Birner-Gruenberger R, Vujić N, Kratky D. Akhmetshina A, et al. Among authors: kolb d. Mol Metab. 2024 Jan;79:101869. doi: 10.1016/j.molmet.2023.101869. Epub 2023 Dec 30. Mol Metab. 2024. PMID: 38160938 Free PMC article.
Efficient phagocytosis requires triacylglycerol hydrolysis by adipose triglyceride lipase.
Chandak PG, Radovic B, Aflaki E, Kolb D, Buchebner M, Fröhlich E, Magnes C, Sinner F, Haemmerle G, Zechner R, Tabas I, Levak-Frank S, Kratky D. Chandak PG, et al. Among authors: kolb d. J Biol Chem. 2010 Jun 25;285(26):20192-201. doi: 10.1074/jbc.M110.107854. Epub 2010 Apr 27. J Biol Chem. 2010. PMID: 20424161 Free PMC article.
Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages.
Aflaki E, Radovic B, Chandak PG, Kolb D, Eisenberg T, Ring J, Fertschai I, Uellen A, Wolinski H, Kohlwein SD, Zechner R, Levak-Frank S, Sattler W, Graier WF, Malli R, Madeo F, Kratky D. Aflaki E, et al. Among authors: kolb d. J Biol Chem. 2011 Mar 4;286(9):7418-28. doi: 10.1074/jbc.M110.175703. Epub 2011 Jan 1. J Biol Chem. 2011. PMID: 21196579 Free PMC article.
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. Haemmerle G, et al. Among authors: kolb d. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439. Nat Med. 2011. PMID: 21857651 Free PMC article.
C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages.
Aflaki E, Doddapattar P, Radović B, Povoden S, Kolb D, Vujić N, Wegscheider M, Koefeler H, Hornemann T, Graier WF, Malli R, Madeo F, Kratky D. Aflaki E, et al. Among authors: kolb d. Cell Death Dis. 2012 Mar 15;3(3):e280. doi: 10.1038/cddis.2012.17. Cell Death Dis. 2012. PMID: 22419109 Free PMC article.
Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.
Doddapattar P, Radović B, Patankar JV, Obrowsky S, Jandl K, Nusshold C, Kolb D, Vujić N, Doshi L, Chandak PG, Goeritzer M, Ahammer H, Hoefler G, Sattler W, Kratky D. Doddapattar P, et al. Among authors: kolb d. Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3. Mol Nutr Food Res. 2013. PMID: 23650230 Free PMC article.
Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis.
Goeritzer M, Schlager S, Radovic B, Madreiter CT, Rainer S, Thomas G, Lord CC, Sacks J, Brown AL, Vujic N, Obrowsky S, Sachdev V, Kolb D, Chandak PG, Graier WF, Sattler W, Brown JM, Kratky D. Goeritzer M, et al. Among authors: kolb d. J Lipid Res. 2014 Dec;55(12):2562-75. doi: 10.1194/jlr.M052613. Epub 2014 Oct 14. J Lipid Res. 2014. PMID: 25316883 Free PMC article.
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
Jaeger D, Schoiswohl G, Hofer P, Schreiber R, Schweiger M, Eichmann TO, Pollak NM, Poecher N, Grabner GF, Zierler KA, Eder S, Kolb D, Radner FP, Preiss-Landl K, Lass A, Zechner R, Kershaw EE, Haemmerle G. Jaeger D, et al. Among authors: kolb d. J Hepatol. 2015 Aug;63(2):437-45. doi: 10.1016/j.jhep.2015.02.035. Epub 2015 Feb 27. J Hepatol. 2015. PMID: 25733154 Free PMC article.
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
Schlager S, Goeritzer M, Jandl K, Frei R, Vujic N, Kolb D, Strohmaier H, Dorow J, Eichmann TO, Rosenberger A, Wölfler A, Lass A, Kershaw EE, Ceglarek U, Dichlberger A, Heinemann A, Kratky D. Schlager S, et al. Among authors: kolb d. J Leukoc Biol. 2015 Nov;98(5):837-50. doi: 10.1189/jlb.3A0515-206R. Epub 2015 Jun 24. J Leukoc Biol. 2015. PMID: 26109679 Free PMC article.
200 results