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Glutarate regulates T cell metabolism and anti-tumour immunity.
Minogue E, Cunha PP, Wadsworth BJ, Grice GL, Sah-Teli SK, Hughes R, Bargiela D, Quaranta A, Zurita J, Antrobus R, Velica P, Barbieri L, Wheelock CE, Koivunen P, Nathan JA, Foskolou IP, Johnson RS. Minogue E, et al. Among authors: koivunen p. Nat Metab. 2023 Oct;5(10):1747-1764. doi: 10.1038/s42255-023-00855-2. Epub 2023 Aug 21. Nat Metab. 2023. PMID: 37605057 Free PMC article.
Iron drives anabolic metabolism through active histone demethylation and mTORC1.
Shapiro JS, Chang HC, Tatekoshi Y, Zhao Z, Waxali ZS, Hong BJ, Chen H, Geier JA, Bartom ET, De Jesus A, Nejad FK, Mahmoodzadeh A, Sato T, Ramos-Alonso L, Romero AM, Martinez-Pastor MT, Jiang SC, Sah-Teli SK, Li L, Bentrem D, Lopaschuk G, Ben-Sahra I, O'Halloran TV, Shilatifard A, Puig S, Bergelson J, Koivunen P, Ardehali H. Shapiro JS, et al. Among authors: koivunen p. Nat Cell Biol. 2023 Oct;25(10):1478-1494. doi: 10.1038/s41556-023-01225-6. Epub 2023 Sep 25. Nat Cell Biol. 2023. PMID: 37749225
2-Oxoglutarate-dependent dioxygenases in cancer.
Losman JA, Koivunen P, Kaelin WG Jr. Losman JA, et al. Among authors: koivunen p. Nat Rev Cancer. 2020 Dec;20(12):710-726. doi: 10.1038/s41568-020-00303-3. Epub 2020 Oct 21. Nat Rev Cancer. 2020. PMID: 33087883 Review.
A histone methylation-MAPK signaling axis drives durable epithelial-mesenchymal transition in hypoxic pancreatic cancer.
Brown BA, Myers PJ, Adair SJ, Pitarresi JR, Sah-Teli SK, Campbell LA, Hart WS, Barbeau MC, Leong K, Seyler N, Kane W, Lee KE, Stelow E, Jones M, Simon MC, Koivunen P, Bauer TW, Stanger BZ, Lazzara MJ. Brown BA, et al. Among authors: koivunen p. Cancer Res. 2024 Mar 12. doi: 10.1158/0008-5472.CAN-22-2945. Online ahead of print. Cancer Res. 2024. PMID: 38471099
Structural basis of homo- and heterotrimerization of collagen I.
Sharma U, Carrique L, Vadon-Le Goff S, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes DJ. Sharma U, et al. Among authors: koivunen p. Nat Commun. 2017 Mar 10;8:14671. doi: 10.1038/ncomms14671. Nat Commun. 2017. PMID: 28281531 Free PMC article.
HIF-1α is upregulated in human mesenchymal stem cells.
Palomäki S, Pietilä M, Laitinen S, Pesälä J, Sormunen R, Lehenkari P, Koivunen P. Palomäki S, et al. Among authors: koivunen p. Stem Cells. 2013 Sep;31(9):1902-9. doi: 10.1002/stem.1435. Stem Cells. 2013. PMID: 23744828
210 results