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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1.
Kryza T, Khan T, Lovell S, Harrington BS, Yin J, Porazinski S, Pajic M, Koistinen H, Rantala JK, Dreyer T, Magdolen V, Reuning U, He Y, Tate EW, Hooper JD. Kryza T, et al. Among authors: koistinen h. Nat Chem Biol. 2021 Jul;17(7):776-783. doi: 10.1038/s41589-021-00783-w. Epub 2021 Apr 15. Nat Chem Biol. 2021. PMID: 33859413
The roles of proteases in prostate cancer.
Koistinen H, Kovanen RM, Hollenberg MD, Dufour A, Radisky ES, Stenman UH, Batra J, Clements J, Hooper JD, Diamandis E, Schilling O, Rannikko A, Mirtti T. Koistinen H, et al. IUBMB Life. 2023 Jun;75(6):493-513. doi: 10.1002/iub.2700. Epub 2023 Jan 4. IUBMB Life. 2023. PMID: 36598826 Review.
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products.
Ahmed MN, Wahlsten M, Jokela J, Nees M, Stenman UH, Alvarenga DO, Strandin T, Sivonen K, Poso A, Permi P, Metsä-Ketelä M, Koistinen H, Fewer DP. Ahmed MN, et al. Among authors: koistinen h. ACS Chem Biol. 2021 Nov 19;16(11):2537-2546. doi: 10.1021/acschembio.1c00611. Epub 2021 Oct 18. ACS Chem Biol. 2021. PMID: 34661384 Free PMC article.
Altered glycosylation of glycodelin in endometrial carcinoma.
Hautala LC, Pang PC, Antonopoulos A, Pasanen A, Lee CL, Chiu PCN, Yeung WSB, Loukovaara M, Bützow R, Haslam SM, Dell A, Koistinen H. Hautala LC, et al. Among authors: koistinen h. Lab Invest. 2020 Jul;100(7):1014-1025. doi: 10.1038/s41374-020-0411-x. Epub 2020 Mar 23. Lab Invest. 2020. PMID: 32205858 Free PMC article.
Specificity profiling of human trypsin-isoenzymes.
Schilling O, Biniossek ML, Mayer B, Elsässer B, Brandstetter H, Goettig P, Stenman UH, Koistinen H. Schilling O, et al. Among authors: koistinen h. Biol Chem. 2018 Sep 25;399(9):997-1007. doi: 10.1515/hsz-2018-0107. Biol Chem. 2018. PMID: 29883318
Discovery of varlaxins, new aeruginosin-type inhibitors of human trypsins.
Heinilä LMP, Jokela J, Ahmed MN, Wahlsten M, Kumar S, Hrouzek P, Permi P, Koistinen H, Fewer DP, Sivonen K. Heinilä LMP, et al. Among authors: koistinen h. Org Biomol Chem. 2022 Mar 30;20(13):2681-2692. doi: 10.1039/d1ob02454j. Org Biomol Chem. 2022. PMID: 35293909
238 results