Koide S - Search Results

1

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E. Röck R, et al. Among authors: koide s. Sci Adv. 2019 Aug 14;5(8):eaav8463. doi: 10.1126/sciadv.aav8463. eCollection 2019 Aug. Sci Adv. 2019. PMID: 31453322 Free PMC article.

2

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.

Spencer-Smith R, Li L, Prasad S, Koide A, Koide S, O'Bryan JP. Spencer-Smith R, et al. Among authors: koide s, koide a. Small GTPases. 2019 Sep;10(5):378-387. doi: 10.1080/21541248.2017.1333188. Epub 2017 Dec 31. Small GTPases. 2019. PMID: 28692342 Free PMC article.

3

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket.

Wallon L, Khan I, Teng KW, Koide A, Zuberi M, Li J, Ketavarapu G, Traaseth NJ, O'Bryan JP, Koide S. Wallon L, et al. Among authors: koide s, koide a. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2204481119. doi: 10.1073/pnas.2204481119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252024 Free PMC article.

4

Inhibition of RAS function through targeting an allosteric regulatory site.

Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, Okur MN, Dementieva I, Sicheri F, Therrien M, Hancock JF, Ikura M, Koide S, O'Bryan JP. Spencer-Smith R, et al. Among authors: koide s, koide a. Nat Chem Biol. 2017 Jan;13(1):62-68. doi: 10.1038/nchembio.2231. Epub 2016 Nov 7. Nat Chem Biol. 2017. PMID: 27820802 Free PMC article.

5

Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Lee KY, Fang Z, Enomoto M, Gasmi-Seabrook G, Zheng L, Koide S, Ikura M, Marshall CB. Lee KY, et al. Among authors: koide s. Angew Chem Int Ed Engl. 2020 Jun 26;59(27):11037-11045. doi: 10.1002/anie.202001758. Epub 2020 Apr 30. Angew Chem Int Ed Engl. 2020. PMID: 32227412 Free PMC article.

6

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.

Fedele C, Li S, Teng KW, Foster CJR, Peng D, Ran H, Mita P, Geer MJ, Hattori T, Koide A, Wang Y, Tang KH, Leinwand J, Wang W, Diskin B, Deng J, Chen T, Dolgalev I, Ozerdem U, Miller G, Koide S, Wong KK, Neel BG. Fedele C, et al. Among authors: koide s, koide a. J Exp Med. 2021 Jan 4;218(1):e20201414. doi: 10.1084/jem.20201414. J Exp Med. 2021. PMID: 33045063 Free PMC article.

7

Selective and noncovalent targeting of RAS mutants for inhibition and degradation.

Teng KW, Tsai ST, Hattori T, Fedele C, Koide A, Yang C, Hou X, Zhang Y, Neel BG, O'Bryan JP, Koide S. Teng KW, et al. Among authors: koide s, koide a. Nat Commun. 2021 May 11;12(1):2656. doi: 10.1038/s41467-021-22969-5. Nat Commun. 2021. PMID: 33976200 Free PMC article.

8

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Khan I, Koide A, Zuberi M, Ketavarapu G, Denbaum E, Teng KW, Rhett JM, Spencer-Smith R, Hobbs GA, Camp ER, Koide S, O'Bryan JP. Khan I, et al. Among authors: koide s, koide a. Cell Rep. 2022 Feb 8;38(6):110322. doi: 10.1016/j.celrep.2022.110322. Cell Rep. 2022. PMID: 35139380 Free PMC article.

9

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.

Akkapeddi P, Hattori T, Khan I, Glasser E, Koide A, Ketavarapu G, Whaby M, Zuberi M, Teng KW, Lefler J, Maso L, Bang I, Ostrowski MC, O'Bryan JP, Koide S. Akkapeddi P, et al. Among authors: koide s, koide a. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2302485120. doi: 10.1073/pnas.2302485120. Epub 2023 Jul 3. Proc Natl Acad Sci U S A. 2023. PMID: 37399416 Free PMC article.

10

Monobodies and other synthetic binding proteins for expanding protein science.

Sha F, Salzman G, Gupta A, Koide S. Sha F, et al. Among authors: koide s. Protein Sci. 2017 May;26(5):910-924. doi: 10.1002/pro.3148. Epub 2017 Mar 24. Protein Sci. 2017. PMID: 28249355 Free PMC article. Review.

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