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Discovery of 2-Sulfinyl-Diazabicyclooctane Derivatives, Potential Oral β-Lactamase Inhibitors for Infections Caused by Serine β-Lactamase-Producing Enterobacterales.
Fujiu M, Yokoo K, Sato J, Shibuya S, Komano K, Kusano H, Sato S, Aoki T, Kohira N, Kanazawa S, Watari R, Kawachi T, Hirakawa Y, Nagamatsu D, Kashiwagi E, Maki H, Yamawaki K. Fujiu M, et al. Among authors: kohira n. J Med Chem. 2021 Jul 8;64(13):9496-9512. doi: 10.1021/acs.jmedchem.1c00799. Epub 2021 Jun 18. J Med Chem. 2021. PMID: 34143627
Introduction of a Thio Functional Group to Diazabicyclooctane: An Effective Modification to Potentiate the Activity of β-Lactams against Gram-Negative Bacteria Producing Class A, C, and D Serine β-Lactamases.
Fujiu M, Yokoo K, Sato J, Shibuya S, Komano K, Kusano H, Sato S, Aoki T, Kohira N, Miyagawa S, Kawachi T, Yamawaki K. Fujiu M, et al. Among authors: kohira n. ACS Infect Dis. 2020 Nov 13;6(11):3034-3047. doi: 10.1021/acsinfecdis.0c00560. Epub 2020 Nov 4. ACS Infect Dis. 2020. PMID: 33147950
In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria.
Ito A, Sato T, Ota M, Takemura M, Nishikawa T, Toba S, Kohira N, Miyagawa S, Ishibashi N, Matsumoto S, Nakamura R, Tsuji M, Yamano Y. Ito A, et al. Among authors: kohira n. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01454-17. doi: 10.1128/AAC.01454-17. Print 2018 Jan. Antimicrob Agents Chemother. 2017. PMID: 29061741 Free PMC article.
Susceptibility of Imipenem-Susceptible but Meropenem-Resistant blaIMP-6-Carrying Enterobacteriaceae to Various Antibacterials, Including the Siderophore Cephalosporin Cefiderocol.
Kanazawa S, Sato T, Kohira N, Ito-Horiyama T, Tsuji M, Yamano Y. Kanazawa S, et al. Among authors: kohira n. Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00576-17. doi: 10.1128/AAC.00576-17. Print 2017 Jul. Antimicrob Agents Chemother. 2017. PMID: 28438934 Free PMC article. No abstract available.
In vitro antimicrobial activity of S-649266, a catechol-substituted siderophore cephalosporin, when tested against non-fermenting Gram-negative bacteria.
Ito A, Kohira N, Bouchillon SK, West J, Rittenhouse S, Sader HS, Rhomberg PR, Jones RN, Yoshizawa H, Nakamura R, Tsuji M, Yamano Y. Ito A, et al. Among authors: kohira n. J Antimicrob Chemother. 2016 Mar;71(3):670-7. doi: 10.1093/jac/dkv402. Epub 2015 Dec 7. J Antimicrob Chemother. 2016. PMID: 26645269
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