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Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo.
Ramos TL, Bolivar-Wagers S, Jin S, Thangavelu G, Simonetta F, Lin PY, Hirai T, Saha A, Koehn B, Su LL, Picton LK, Baker J, Lohmeyer JK, Riddle M, Eide C, Tolar J, Panoskaltsis-Mortari A, Wagner JE, Garcia KC, Negrin RS, Blazar BR. Ramos TL, et al. Among authors: koehn b. Blood. 2023 Mar 16;141(11):1337-1352. doi: 10.1182/blood.2022018440. Blood. 2023. PMID: 36564052 Free PMC article.
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Highfill SL, Rodriguez PC, Zhou Q, Goetz CA, Koehn BH, Veenstra R, Taylor PA, Panoskaltsis-Mortari A, Serody JS, Munn DH, Tolar J, Ochoa AC, Blazar BR. Highfill SL, et al. Blood. 2010 Dec 16;116(25):5738-47. doi: 10.1182/blood-2010-06-287839. Epub 2010 Aug 31. Blood. 2010. PMID: 20807889 Free PMC article.
Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.
Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR. Saha A, et al. Blood. 2013 Oct 24;122(17):3062-73. doi: 10.1182/blood-2013-05-500801. Epub 2013 Sep 12. Blood. 2013. PMID: 24030385 Free PMC article.
Bystander activation and anti-tumor effects of CD8+ T cells following Interleukin-2 based immunotherapy is independent of CD4+ T cell help.
Monjazeb AM, Tietze JK, Grossenbacher SK, Hsiao HH, Zamora AE, Mirsoian A, Koehn B, Blazar BR, Weiss JM, Wiltrout RH, Sckisel GD, Murphy WJ. Monjazeb AM, et al. Among authors: koehn b. PLoS One. 2014 Aug 13;9(8):e102709. doi: 10.1371/journal.pone.0102709. eCollection 2014. PLoS One. 2014. PMID: 25119341 Free PMC article.
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.
Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR. Reichenbach DK, et al. Blood. 2015 May 14;125(20):3183-92. doi: 10.1182/blood-2014-10-606830. Epub 2015 Mar 26. Blood. 2015. PMID: 25814531 Free PMC article.
Inflammasome effects in GvHD.
Koehn BH, Zeiser R, Blazar BR. Koehn BH, et al. Oncotarget. 2015 Nov 17;6(36):38444-5. doi: 10.18632/oncotarget.6307. Oncotarget. 2015. PMID: 26564963 Free PMC article. No abstract available.
29 results