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Laminin-5γ-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration, and invasion by modulating signaling of EGFR.
Garg M, Kanojia D, Okamoto R, Jain S, Madan V, Chien W, Sampath A, Ding LW, Xuan M, Said JW, Doan NB, Liu LZ, Yang H, Gery S, Braunstein GD, Koeffler HP. Garg M, et al. Among authors: koeffler hp. J Clin Endocrinol Metab. 2014 Jan;99(1):E62-72. doi: 10.1210/jc.2013-2994. Epub 2013 Dec 20. J Clin Endocrinol Metab. 2014. PMID: 24170107 Free PMC article.
Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
Ding LW, Sun QY, Tan KT, Chien W, Mayakonda A, Yeoh AEJ, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernández LT, Hema Preethi SS, Lill M, Kantarjian HM, Kornblau SM, Miyano S, Liang DC, Ogawa S, Shih LY, Yang H, Koeffler HP. Ding LW, et al. Among authors: koeffler hp. Cancer Res. 2017 Jan 15;77(2):390-400. doi: 10.1158/0008-5472.CAN-16-1303. Epub 2016 Nov 21. Cancer Res. 2017. PMID: 27872090 Free PMC article.
BCL6 promotes glioma and serves as a therapeutic target.
Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP. Xu L, et al. Among authors: koeffler hp. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Epub 2017 Mar 29. Proc Natl Acad Sci U S A. 2017. PMID: 28356518 Free PMC article.
Targeting the vulnerability to NAD+ depletion in B-cell acute lymphoblastic leukemia.
Takao S, Chien W, Madan V, Lin DC, Ding LW, Sun QY, Mayakonda A, Sudo M, Xu L, Chen Y, Jiang YY, Gery S, Lill M, Park E, Senapedis W, Baloglu E, Müschen M, Koeffler HP. Takao S, et al. Among authors: koeffler hp. Leukemia. 2018 Mar;32(3):616-625. doi: 10.1038/leu.2017.281. Epub 2017 Sep 14. Leukemia. 2018. PMID: 28904384
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma.
Xu L, Chen Y, Mayakonda A, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RY, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP. Xu L, et al. Among authors: koeffler hp. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095. doi: 10.1073/pnas.1712363115. Epub 2018 May 15. Proc Natl Acad Sci U S A. 2018. PMID: 29764999 Free PMC article.
841 results