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Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody.
Nishiwaki N, Noma K, Ohara T, Kunitomo T, Kawasaki K, Akai M, Kobayashi T, Narusaka T, Kashima H, Sato H, Komoto S, Kato T, Maeda N, Kikuchi S, Tanabe S, Tazawa H, Shirakawa Y, Fujiwara T. Nishiwaki N, et al. Among authors: kobayashi t. Cancer Immunol Immunother. 2023 Jul;72(7):2029-2044. doi: 10.1007/s00262-023-03378-7. Epub 2023 Feb 10. Cancer Immunol Immunother. 2023. PMID: 36764954 Free PMC article.
Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer.
Katsube R, Noma K, Ohara T, Nishiwaki N, Kobayashi T, Komoto S, Sato H, Kashima H, Kato T, Kikuchi S, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T. Katsube R, et al. Among authors: kobayashi h, kobayashi t. Sci Rep. 2021 Jan 18;11(1):1693. doi: 10.1038/s41598-021-81465-4. Sci Rep. 2021. PMID: 33462372 Free PMC article.
Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment.
Sato H, Noma K, Ohara T, Kawasaki K, Akai M, Kobayashi T, Nishiwaki N, Narusaka T, Komoto S, Kashima H, Katsura Y, Kato T, Kikuchi S, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T. Sato H, et al. Among authors: kobayashi h, kobayashi t. Sci Rep. 2022 Nov 23;12(1):20152. doi: 10.1038/s41598-022-24313-3. Sci Rep. 2022. PMID: 36418422 Free PMC article.
Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models.
Komoto S, Noma K, Kato T, Kobayashi T, Nishiwaki N, Narusaka T, Sato H, Katsura Y, Kashima H, Kikuchi S, Ohara T, Tazawa H, Fujiwara T. Komoto S, et al. Among authors: kobayashi t. Cancers (Basel). 2023 May 30;15(11):2971. doi: 10.3390/cancers15112971. Cancers (Basel). 2023. PMID: 37296933 Free PMC article.
PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer.
Kawasaki K, Noma K, Kato T, Ohara T, Tanabe S, Takeda Y, Matsumoto H, Nishimura S, Kunitomo T, Akai M, Kobayashi T, Nishiwaki N, Kashima H, Maeda N, Kikuchi S, Tazawa H, Shirakawa Y, Fujiwara T. Kawasaki K, et al. Among authors: kobayashi t. Cancer Immunol Immunother. 2023 Nov;72(11):3787-3802. doi: 10.1007/s00262-023-03531-2. Epub 2023 Sep 5. Cancer Immunol Immunother. 2023. PMID: 37668710 Free PMC article.
Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity.
Akai M, Noma K, Kato T, Nishimura S, Matsumoto H, Kawasaki K, Kunitomo T, Kobayashi T, Nishiwaki N, Kashima H, Kikuchi S, Ohara T, Tazawa H, Choyke PL, Kobayashi H, Fujiwara T. Akai M, et al. Among authors: kobayashi h, kobayashi t. Br J Cancer. 2024 Jun;130(10):1647-1658. doi: 10.1038/s41416-024-02639-1. Epub 2024 Mar 30. Br J Cancer. 2024. PMID: 38555315 Free PMC article.
Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts using a Humanized anti-Fibroblast Activation Protein Antibody.
Kobayashi T, Noma K, Nishimura S, Kato T, Nishiwaki N, Ohara T, Kunitomo T, Kawasaki K, Akai M, Komoto S, Kashima H, Kikuchi S, Tazawa H, Shirakawa Y, Choyke PL, Kobayashi H, Fujiwara T. Kobayashi T, et al. Among authors: kobayashi h. Mol Cancer Ther. 2024 Apr 18. doi: 10.1158/1535-7163.MCT-23-0527. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38638034
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