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SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.
Chen S, Bonifati S, Qin Z, St Gelais C, Kodigepalli KM, Barrett BS, Kim SH, Antonucci JM, Ladner KJ, Buzovetsky O, Knecht KM, Xiong Y, Yount JS, Guttridge DC, Santiago ML, Wu L. Chen S, et al. Among authors: knecht km. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3798-E3807. doi: 10.1073/pnas.1801213115. Epub 2018 Apr 2. Proc Natl Acad Sci U S A. 2018. PMID: 29610295 Free PMC article.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, Xiong Y. Knecht KM, et al. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10022-E10031. doi: 10.1073/pnas.1805593115. Epub 2018 Oct 10. Proc Natl Acad Sci U S A. 2018. PMID: 30305425 Free PMC article.
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT, Cinatl J Jr. Oellerich T, et al. Among authors: knecht km. Nat Commun. 2019 Aug 2;10(1):3475. doi: 10.1038/s41467-019-11413-4. Nat Commun. 2019. PMID: 31375673 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 33168627
16 results