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Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.
Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H. Gross CC, et al. Among authors: klotz l. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82. doi: 10.1073/pnas.1524924113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162345 Free PMC article.
The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion.
Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. Hucke S, et al. Among authors: klotz l. Acta Neuropathol. 2016 Sep;132(3):413-31. doi: 10.1007/s00401-016-1593-6. Epub 2016 Jul 6. Acta Neuropathol. 2016. PMID: 27383204
B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.
Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H. Klotz L, et al. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6182-E6191. doi: 10.1073/pnas.1601350113. Epub 2016 Sep 26. Proc Natl Acad Sci U S A. 2016. PMID: 27671636 Free PMC article.
Activation of FXR pathway does not alter glial cell function.
Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T. Albrecht S, et al. Among authors: klotz l. J Neuroinflammation. 2017 Mar 28;14(1):66. doi: 10.1186/s12974-017-0833-6. J Neuroinflammation. 2017. PMID: 28351411 Free PMC article.
Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity.
Liebmann M, Hucke S, Koch K, Eschborn M, Ghelman J, Chasan AI, Glander S, Schädlich M, Kuhlencord M, Daber NM, Eveslage M, Beyer M, Dietrich M, Albrecht P, Stoll M, Busch KB, Wiendl H, Roth J, Kuhlmann T, Klotz L. Liebmann M, et al. Among authors: klotz l. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8017-E8026. doi: 10.1073/pnas.1721049115. Epub 2018 Aug 2. Proc Natl Acad Sci U S A. 2018. PMID: 30072431 Free PMC article.
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome.
Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. Gross CC, et al. Among authors: klotz l. Nat Commun. 2019 Dec 18;10(1):5779. doi: 10.1038/s41467-019-13593-5. Nat Commun. 2019. PMID: 31852955 Free PMC article.
1,045 results