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Page 1
Systematic Investigation of Polyurethane Biomaterial Surface Roughness on Human Immune Responses in vitro.
Segan S, Jakobi M, Khokhani P, Klimosch S, Billing F, Schneider M, Martin D, Metzger U, Biesemeier A, Xiong X, Mukherjee A, Steuer H, Keller BM, Joos T, Schmolz M, Rothbauer U, Hartmann H, Burkhardt C, Lorenz G, Schneiderhan-Marra N, Shipp C. Segan S, et al. Among authors: klimosch s. Biomed Res Int. 2020 May 11;2020:3481549. doi: 10.1155/2020/3481549. eCollection 2020. Biomed Res Int. 2020. PMID: 32461979 Free PMC article.
A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance.
Wang H, El Maadidi S, Fischer J, Grabski E, Dickhöfer S, Klimosch S, Flannery SM, Filomena A, Wolz OO, Schneiderhan-Marra N, Löffler MW, Wiese M, Pichulik T, Müllhaupt B, Semela D, Dufour JF, Bochud PY, Bowie AG, Kalinke U, Berg T, Weber AN; East-German and Swiss Hepatitis C Virus Study Groups. Wang H, et al. Among authors: klimosch s. Hepatology. 2015 Nov;62(5):1375-87. doi: 10.1002/hep.28105. Epub 2015 Sep 28. Hepatology. 2015. PMID: 26250868
Putative link between Polo-like kinases (PLKs) and Toll-like receptor (TLR) signaling in transformed and primary human immune cells.
El Maadidi S, Weber ANR, Motshwene P, Schüssler JM, Backes D, Dickhöfer S, Wang H, Liu X, Garcia MD, Taumer C, Soufi B, Wolz OO, Klimosch SN, Franz-Wachtel M, Macek B, Gay NJ. El Maadidi S, et al. Among authors: klimosch sn. Sci Rep. 2019 Sep 11;9(1):13168. doi: 10.1038/s41598-019-49017-z. Sci Rep. 2019. PMID: 31511529 Free PMC article.
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.
Colak E, Leslie A, Zausmer K, Khatamzas E, Kubarenko AV, Pichulik T, Klimosch SN, Mayer A, Siggs O, Hector A, Fischer R, Klesser B, Rautanen A, Frank M, Hill AV, Manoury B, Beutler B, Hartl D, Simmons A, Weber AN. Colak E, et al. Among authors: klimosch sn. J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9. J Immunol. 2014. PMID: 24813206 Free PMC article.
Functional TLR5 genetic variants affect human colorectal cancer survival.
Klimosch SN, Försti A, Eckert J, Knezevic J, Bevier M, von Schönfels W, Heits N, Walter J, Hinz S, Lascorz J, Hampe J, Hartl D, Frick JS, Hemminki K, Schafmayer C, Weber AN. Klimosch SN, et al. Cancer Res. 2013 Dec 15;73(24):7232-42. doi: 10.1158/0008-5472.CAN-13-1746. Epub 2013 Oct 23. Cancer Res. 2013. PMID: 24154872
Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.
Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D. Rieber N, et al. Among authors: klimosch sn. Cell Host Microbe. 2015 Apr 8;17(4):507-14. doi: 10.1016/j.chom.2015.02.007. Epub 2015 Mar 12. Cell Host Microbe. 2015. PMID: 25771792 Free PMC article.