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Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Smole A, et al. Among authors: klichinsky m. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. Cancer Cell. 2022. PMID: 36513049 Free PMC article.
Macrophage-Based Approaches for Cancer Immunotherapy.
Anderson NR, Minutolo NG, Gill S, Klichinsky M. Anderson NR, et al. Among authors: klichinsky m. Cancer Res. 2021 Mar 1;81(5):1201-1208. doi: 10.1158/0008-5472.CAN-20-2990. Epub 2020 Nov 17. Cancer Res. 2021. PMID: 33203697 Review.
Human chimeric antigen receptor macrophages for cancer immunotherapy.
Klichinsky M, Ruella M, Shestova O, Lu XM, Best A, Zeeman M, Schmierer M, Gabrusiewicz K, Anderson NR, Petty NE, Cummins KD, Shen F, Shan X, Veliz K, Blouch K, Yashiro-Ohtani Y, Kenderian SS, Kim MY, O'Connor RS, Wallace SR, Kozlowski MS, Marchione DM, Shestov M, Garcia BA, June CH, Gill S. Klichinsky M, et al. Nat Biotechnol. 2020 Aug;38(8):947-953. doi: 10.1038/s41587-020-0462-y. Epub 2020 Mar 23. Nat Biotechnol. 2020. PMID: 32361713 Free PMC article.
Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.
Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ. Ruella M, et al. Among authors: klichinsky m. Nat Med. 2018 Oct;24(10):1499-1503. doi: 10.1038/s41591-018-0201-9. Epub 2018 Oct 1. Nat Med. 2018. PMID: 30275568 Free PMC article.
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Kim MY, Yu KR, Kenderian SS, Ruella M, Chen S, Shin TH, Aljanahi AA, Schreeder D, Klichinsky M, Shestova O, Kozlowski MS, Cummins KD, Shan X, Shestov M, Bagg A, Morrissette JJD, Sekhri P, Lazzarotto CR, Calvo KR, Kuhns DB, Donahue RE, Behbehani GK, Tsai SQ, Dunbar CE, Gill S. Kim MY, et al. Among authors: klichinsky m. Cell. 2018 May 31;173(6):1439-1453.e19. doi: 10.1016/j.cell.2018.05.013. Epub 2018 May 31. Cell. 2018. PMID: 29856956 Free PMC article.
Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies.
Ruella M, Barrett DM, Kenderian SS, Shestova O, Hofmann TJ, Perazzelli J, Klichinsky M, Aikawa V, Nazimuddin F, Kozlowski M, Scholler J, Lacey SF, Melenhorst JJ, Morrissette JJ, Christian DA, Hunter CA, Kalos M, Porter DL, June CH, Grupp SA, Gill S. Ruella M, et al. Among authors: klichinsky m. J Clin Invest. 2016 Oct 3;126(10):3814-3826. doi: 10.1172/JCI87366. Epub 2016 Aug 29. J Clin Invest. 2016. PMID: 27571406 Free PMC article.
The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.
Ruella M, Kenderian SS, Shestova O, Fraietta JA, Qayyum S, Zhang Q, Maus MV, Liu X, Nunez-Cruz S, Klichinsky M, Kawalekar OU, Milone M, Lacey SF, Mato A, Schuster SJ, Kalos M, June CH, Gill S, Wasik MA. Ruella M, et al. Among authors: klichinsky m. Clin Cancer Res. 2016 Jun 1;22(11):2684-96. doi: 10.1158/1078-0432.CCR-15-1527. Epub 2016 Jan 27. Clin Cancer Res. 2016. PMID: 26819453
14 results