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The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Friščić J, Böttcher M, Reinwald C, Bruns H, Wirth B, Popp SJ, Walker KI, Ackermann JA, Chen X, Turner J, Zhu H, Seyler L, Euler M, Kirchner P, Krüger R, Ekici AB, Major T, Aust O, Weidner D, Fischer A, Andes FT, Stanojevic Z, Trajkovic V, Herrmann M, Korb-Pap A, Wank I, Hess A, Winter J, Wixler V, Distler J, Steiner G, Kiener HP, Frey B, Kling L, Raza K, Frey S, Kleyer A, Bäuerle T, Hughes TR, Grüneboom A, Steffen U, Krönke G, Croft AP, Filer A, Köhl J, Klein K, Buckley CD, Schett G, Mougiakakos D, Hoffmann MH. Friščić J, et al. Among authors: kleyer a. Immunity. 2021 May 11;54(5):1002-1021.e10. doi: 10.1016/j.immuni.2021.03.003. Epub 2021 Mar 23. Immunity. 2021. PMID: 33761330 Free article.
PPARβ/δ governs Wnt signaling and bone turnover.
Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. Scholtysek C, et al. Among authors: kleyer a. Nat Med. 2013 May;19(5):608-13. doi: 10.1038/nm.3146. Epub 2013 Mar 31. Nat Med. 2013. PMID: 23542786
Arthritis and bone loss: a hen and egg story.
Kleyer A, Schett G. Kleyer A, et al. Curr Opin Rheumatol. 2014 Jan;26(1):80-4. doi: 10.1097/BOR.0000000000000007. Curr Opin Rheumatol. 2014. PMID: 24276089 Review.
Th2 and eosinophil responses suppress inflammatory arthritis.
Chen Z, Andreev D, Oeser K, Krljanac B, Hueber A, Kleyer A, Voehringer D, Schett G, Bozec A. Chen Z, et al. Among authors: kleyer a. Nat Commun. 2016 Jun 7;7:11596. doi: 10.1038/ncomms11596. Nat Commun. 2016. PMID: 27273006 Free PMC article.
Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease.
Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Böhm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lönnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Blüml S, Nimmerjahn F, Schett G, Krönke G. Pfeifle R, et al. Among authors: kleyer a. Nat Immunol. 2017 Jan;18(1):104-113. doi: 10.1038/ni.3579. Epub 2016 Nov 7. Nat Immunol. 2017. PMID: 27820809 Free PMC article.
Cutting Edge: Homeostasis of Innate Lymphoid Cells Is Imbalanced in Psoriatic Arthritis.
Soare A, Weber S, Maul L, Rauber S, Gheorghiu AM, Luber M, Houssni I, Kleyer A, von Pickardt G, Gado M, Simon D, Rech J, Schett G, Distler JHW, Ramming A. Soare A, et al. Among authors: kleyer a. J Immunol. 2018 Feb 15;200(4):1249-1254. doi: 10.4049/jimmunol.1700596. Epub 2018 Jan 12. J Immunol. 2018. PMID: 29330320
155 results