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Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins.
Schoenauer R, Larpin Y, Babiychuk EB, Drücker P, Babiychuk VS, Avota E, Schneider-Schaulies S, Schumacher F, Kleuser B, Köffel R, Draeger A. Schoenauer R, et al. Among authors: kleuser b. FASEB J. 2019 Jan;33(1):275-285. doi: 10.1096/fj.201800033R. Epub 2018 Jul 6. FASEB J. 2019. PMID: 29979630
Yet, in addition to the increased plasmalemmal repair, the enhanced toxin resistance of NSM-2 KD cells also appeared to be dependent on the activation of p38/MAPK, which was constitutively activated, whereas in ASM KD cells, the p38/MAPK activation was constitutively blunted.-Sch …
Yet, in addition to the increased plasmalemmal repair, the enhanced toxin resistance of NSM-2 KD cells also appeared to be dependent on the …
Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in mice.
Henry BD, Neill DR, Becker KA, Gore S, Bricio-Moreno L, Ziobro R, Edwards MJ, Mühlemann K, Steinmann J, Kleuser B, Japtok L, Luginbühl M, Wolfmeier H, Scherag A, Gulbins E, Kadioglu A, Draeger A, Babiychuk EB. Henry BD, et al. Among authors: kleuser b. Nat Biotechnol. 2015 Jan;33(1):81-8. doi: 10.1038/nbt.3037. Epub 2014 Nov 2. Nat Biotechnol. 2015. PMID: 25362245
Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans.
Schumacher F, Chakraborty S, Kleuser B, Gulbins E, Schwerdtle T, Aschner M, Bornhorst J. Schumacher F, et al. Among authors: kleuser b. Talanta. 2015 Nov 1;144:71-9. doi: 10.1016/j.talanta.2015.05.057. Epub 2015 May 28. Talanta. 2015. PMID: 26452793 Free PMC article.
Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes.
Gerecke C, Edlich A, Giulbudagian M, Schumacher F, Zhang N, Said A, Yealland G, Lohan SB, Neumann F, Meinke MC, Ma N, Calderón M, Hedtrich S, Schäfer-Korting M, Kleuser B. Gerecke C, et al. Among authors: kleuser b. Nanotoxicology. 2017 Mar;11(2):267-277. doi: 10.1080/17435390.2017.1292371. Epub 2017 Feb 22. Nanotoxicology. 2017. PMID: 28165853
236 results