Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins.
Schoenauer R, Larpin Y, Babiychuk EB, Drücker P, Babiychuk VS, Avota E, Schneider-Schaulies S, Schumacher F, Kleuser B, Köffel R, Draeger A.
Schoenauer R, et al. Among authors: kleuser b.
FASEB J. 2019 Jan;33(1):275-285. doi: 10.1096/fj.201800033R. Epub 2018 Jul 6.
FASEB J. 2019.
PMID: 29979630
Yet, in addition to the increased plasmalemmal repair, the enhanced toxin resistance of NSM-2 KD cells also appeared to be dependent on the activation of p38/MAPK, which was constitutively activated, whereas in ASM KD cells, the p38/MAPK activation was constitutively blunted.-Sch …
Yet, in addition to the increased plasmalemmal repair, the enhanced toxin resistance of NSM-2 KD cells also appeared to be dependent on the …