Kleinjans JCS - Search Results

1

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches.

Rodrigues D, Souza T, Jennen DGJ, Lemmens L, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: kleinjans jcs. Cancer Treat Rev. 2019 Jul;77:57-66. doi: 10.1016/j.ctrv.2019.06.004. Epub 2019 Jun 27. Cancer Treat Rev. 2019. PMID: 31279169 Free article. Review.

2

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.

Rodrigues D, de Souza T, Coyle L, Di Piazza M, Herpers B, Ferreira S, Zhang M, Vappiani J, Sévin DC, Gabor A, Lynch A, Chung SW, Saez-Rodriguez J, Jennen DGJ, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: kleinjans jcs. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20. Arch Toxicol. 2021. PMID: 34151400 Free PMC article.

3

Development of novel tools for the in vitro investigation of drug-induced liver injury.

Jiang J, Wolters JE, van Breda SG, Kleinjans JC, de Kok TM. Jiang J, et al. Expert Opin Drug Metab Toxicol. 2015;11(10):1523-37. doi: 10.1517/17425255.2015.1065814. Epub 2015 Jul 9. Expert Opin Drug Metab Toxicol. 2015. PMID: 26155718 Review.

4

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis.

Souza T, Jennen D, van Delft J, van Herwijnen M, Kyrtoupolos S, Kleinjans J. Souza T, et al. Arch Toxicol. 2016 Jun;90(6):1449-58. doi: 10.1007/s00204-015-1572-z. Epub 2015 Aug 4. Arch Toxicol. 2016. PMID: 26238291 Free PMC article.

5

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.

Souza T, Trairatphisan P, Piñero J, Furlong LI, Saez-Rodriguez J, Kleinjans J, Jennen D. Souza T, et al. Front Genet. 2018 Nov 20;9:527. doi: 10.3389/fgene.2018.00527. eCollection 2018. Front Genet. 2018. PMID: 30515189 Free PMC article.

6

Transcriptome analysis of long noncoding RNAs reveals their potential roles in anthracycline-induced cardiotoxicity.

Nguyen N, Souza T, Kleinjans J, Jennen D. Nguyen N, et al. Noncoding RNA Res. 2022 Jan 23;7(2):106-113. doi: 10.1016/j.ncrna.2022.01.002. eCollection 2022 Jun. Noncoding RNA Res. 2022. PMID: 35415316 Free PMC article.

7

Omics technologies to understand drug toxicity mechanisms.

Nguyen N, Jennen D, Kleinjans J. Nguyen N, et al. Drug Discov Today. 2022 Nov;27(11):103348. doi: 10.1016/j.drudis.2022.103348. Epub 2022 Sep 8. Drug Discov Today. 2022. PMID: 36089240 Free article. Review.

8

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

Hebels DG, Jennen DG, van Herwijnen MH, Moonen EJ, Pedersen M, Knudsen LE, Kleinjans JC, de Kok TM. Hebels DG, et al. Mutagenesis. 2011 Nov;26(6):753-61. doi: 10.1093/mutage/ger043. Epub 2011 Jul 1. Mutagenesis. 2011. PMID: 21724973

9

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans.

Jetten MJ, Gaj S, Ruiz-Aracama A, de Kok TM, van Delft JH, Lommen A, van Someren EP, Jennen DG, Claessen SM, Peijnenburg AA, Stierum RH, Kleinjans JC. Jetten MJ, et al. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):320-8. doi: 10.1016/j.taap.2012.01.009. Epub 2012 Jan 20. Toxicol Appl Pharmacol. 2012. PMID: 22285215 Clinical Trial.

10

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study.

Hendrickx DM, Jennen DG, Briedé JJ, Cavill R, de Kok TM, Kleinjans JC. Hendrickx DM, et al. Bioinformatics. 2015 Jul 1;31(13):2115-22. doi: 10.1093/bioinformatics/btv108. Epub 2015 Feb 19. Bioinformatics. 2015. PMID: 25701576

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