Kleinjans JC - Search Results

1

Biotransformation pathway maps in WikiPathways enable direct visualization of drug metabolism related expression changes.

Jennen DG, Gaj S, Giesbertz PJ, van Delft JH, Evelo CT, Kleinjans JC. Jennen DG, et al. Among authors: kleinjans jc. Drug Discov Today. 2010 Oct;15(19-20):851-8. doi: 10.1016/j.drudis.2010.08.002. Epub 2010 Aug 11. Drug Discov Today. 2010. PMID: 20708095 Review.

2

Omics technologies to understand drug toxicity mechanisms.

Nguyen N, Jennen D, Kleinjans J. Nguyen N, et al. Drug Discov Today. 2022 Nov;27(11):103348. doi: 10.1016/j.drudis.2022.103348. Epub 2022 Sep 8. Drug Discov Today. 2022. PMID: 36089240 Free article. Review.

3

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells.

Jennen D, Ruiz-Aracama A, Magkoufopoulou C, Peijnenburg A, Lommen A, van Delft J, Kleinjans J. Jennen D, et al. BMC Syst Biol. 2011 Aug 31;5:139. doi: 10.1186/1752-0509-5-139. BMC Syst Biol. 2011. PMID: 21880148 Free PMC article.

4

Assessing the metabolic competence of sandwich-cultured mouse primary hepatocytes.

Mathijs K, Kienhuis AS, Brauers KJ, Jennen DG, Lahoz A, Kleinjans JC, van Delft JH. Mathijs K, et al. Among authors: kleinjans jc. Drug Metab Dispos. 2009 Jun;37(6):1305-11. doi: 10.1124/dmd.108.025775. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251822

5

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH. Jennen DG, et al. Among authors: kleinjans jc. Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27. Toxicol Sci. 2010. PMID: 20106945

6

Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity.

Hebels DG, Jetten MJ, Aerts HJ, Herwig R, Theunissen DH, Gaj S, van Delft JH, Kleinjans JC. Hebels DG, et al. Among authors: kleinjans jc. Biomark Med. 2014;8(2):185-200. doi: 10.2217/bmm.13.154. Biomark Med. 2014. PMID: 24521014 Free article. Review.

7

Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro.

Van den Hof WF, Ruiz-Aracama A, Van Summeren A, Jennen DG, Gaj S, Coonen ML, Brauers K, Wodzig WK, van Delft JH, Kleinjans JC. Van den Hof WF, et al. Among authors: kleinjans jc. Toxicol In Vitro. 2015 Apr;29(3):489-501. doi: 10.1016/j.tiv.2014.12.016. Epub 2015 Jan 3. Toxicol In Vitro. 2015. PMID: 25562108

8

Benzo[a]pyrene-induced changes in microRNA-mRNA networks.

Lizarraga D, Gaj S, Brauers KJ, Timmermans L, Kleinjans JC, van Delft JH. Lizarraga D, et al. Among authors: kleinjans jc. Chem Res Toxicol. 2012 Apr 16;25(4):838-49. doi: 10.1021/tx2003799. Epub 2012 Feb 22. Chem Res Toxicol. 2012. PMID: 22316170

9

Differential gene expression in human peripheral blood mononuclear cells induced by cigarette smoke and its constituents.

van Leeuwen DM, Gottschalk RW, van Herwijnen MH, Moonen EJ, Kleinjans JC, van Delft JH. van Leeuwen DM, et al. Among authors: kleinjans jc. Toxicol Sci. 2005 Jul;86(1):200-10. doi: 10.1093/toxsci/kfi168. Epub 2005 Apr 13. Toxicol Sci. 2005. PMID: 15829617

10

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis.

Hebels DG, Jennen DG, Kleinjans JC, de Kok TM. Hebels DG, et al. Among authors: kleinjans jc. Toxicol Sci. 2009 Apr;108(2):290-300. doi: 10.1093/toxsci/kfp035. Epub 2009 Feb 16. Toxicol Sci. 2009. PMID: 19221148

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