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Potent inhibition of local and disseminated tumor growth in immunocompetent mouse models by a bispecific antibody construct specific for Murine CD3.
Schlereth B, Kleindienst P, Fichtner I, Lorenczewski G, Brischwein K, Lippold S, da Silva A, Locher M, Kischel R, Lutterbüse R, Kufer P, Baeuerle PA. Schlereth B, et al. Among authors: kleindienst p. Cancer Immunol Immunother. 2006 Jul;55(7):785-96. doi: 10.1007/s00262-005-0082-x. Epub 2005 Sep 27. Cancer Immunol Immunother. 2006. PMID: 16187083 Free PMC article.
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA. Brischwein K, et al. Among authors: kleindienst p. Mol Immunol. 2006 Mar;43(8):1129-43. doi: 10.1016/j.molimm.2005.07.034. Epub 2005 Sep 1. Mol Immunol. 2006. PMID: 16139892
Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.
Schlereth B, Fichtner I, Lorenczewski G, Kleindienst P, Brischwein K, da Silva A, Kufer P, Lutterbuese R, Junghahn I, Kasimir-Bauer S, Wimberger P, Kimmig R, Baeuerle PA. Schlereth B, et al. Among authors: kleindienst p. Cancer Res. 2005 Apr 1;65(7):2882-9. doi: 10.1158/0008-5472.CAN-04-2637. Cancer Res. 2005. PMID: 15805290