Klein SI - Search Results

1

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.

Guertin KR, Gardner CJ, Klein SI, Zulli AL, Czekaj M, Gong Y, Spada AP, Cheney DL, Maignan S, Guilloteau JP, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Dunwiddie CT, Leadley RJ, Pauls HW. Guertin KR, et al. Among authors: klein si. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1671-4. doi: 10.1016/s0960-894x(02)00213-5. Bioorg Med Chem Lett. 2002. PMID: 12039587

2

Optimization of the beta-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency.

Czekaj M, Klein SI, Guertin KR, Gardner CJ, Zulli AL, Pauls HW, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Leadley RJ, Dunwiddie CT. Czekaj M, et al. Among authors: klein si. Bioorg Med Chem Lett. 2002 Jun 17;12(12):1667-70. doi: 10.1016/s0960-894x(02)00212-3. Bioorg Med Chem Lett. 2002. PMID: 12039586

3

Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa.

Klein SI, Czekaj M, Gardner CJ, Guertin KR, Cheney DL, Spada AP, Bolton SA, Brown K, Colussi D, Heran CL, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Klein SI, et al. J Med Chem. 1998 Feb 12;41(4):437-50. doi: 10.1021/jm970482y. J Med Chem. 1998. PMID: 9484495

4

Crystal structures of human factor Xa complexed with potent inhibitors.

Maignan S, Guilloteau JP, Pouzieux S, Choi-Sledeski YM, Becker MR, Klein SI, Ewing WR, Pauls HW, Spada AP, Mikol V. Maignan S, et al. Among authors: klein si. J Med Chem. 2000 Aug 24;43(17):3226-32. doi: 10.1021/jm000940u. J Med Chem. 2000. PMID: 10966741

5

Design of a new class of orally active fibrinogen receptor antagonists.

Klein SI, Molino BF, Czekaj M, Gardner CJ, Chu V, Brown K, Sabatino RD, Bostwick JS, Kasiewski C, Bentley R, Windisch V, Perrone M, Dunwiddie CT, Leadley RJ. Klein SI, et al. J Med Chem. 1998 Jul 2;41(14):2492-502. doi: 10.1021/jm9801096. J Med Chem. 1998. PMID: 9651154

6

Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis.

Heran C, Morgan S, Kasiewski C, Bostwick J, Bentley R, Klein S, Chu V, Brown K, Colussi D, Czekaj M, Perrone M, Leadley R Jr. Heran C, et al. Eur J Pharmacol. 2000 Feb 18;389(2-3):201-7. doi: 10.1016/s0014-2999(99)00902-4. Eur J Pharmacol. 2000. PMID: 10688985

7

Superiority of enoxaparin over heparin in combination with a GPIIb/IIIa receptor antagonist during coronary thrombolysis in dogs.

Rebello SS, Kasiewski CJ, Bentley RG, Morgan SR, Chu V, Bostwick JS, Klein SI, Perrone MH, Leadley RJ. Rebello SS, et al. Among authors: klein si. Thromb Res. 2001 May 1;102(3):261-71. doi: 10.1016/s0049-3848(01)00242-0. Thromb Res. 2001. PMID: 11369420

8

A novel series of potent and selective small molecule inhibitors of the complement component C1s.

Subasinghe NL, Ali F, Illig CR, Jonathan Rudolph M, Klein S, Khalil E, Soll RM, Bone RF, Spurlino JC, DesJarlais RL, Crysler CS, Cummings MD, Morris PE Jr, Kilpatrick JM, Sudhakara Babu Y. Subasinghe NL, et al. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3043-7. doi: 10.1016/j.bmcl.2004.04.034. Bioorg Med Chem Lett. 2004. PMID: 15149641

9

Anti-thrombotic activity of RG13965, a novel platelet fibrinogen receptor antagonist.

Bostwick JS, Kasiewski CJ, Chu V, Klein SI, Sabatino RD, Perrone MH, Dunwiddie CT, Cook JJ, Leadley RJ Jr. Bostwick JS, et al. Among authors: klein si. Thromb Res. 1996 Jun 15;82(6):495-507. doi: 10.1016/0049-3848(96)00100-4. Thromb Res. 1996. PMID: 8794522

10

Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.

Youssefyeh RD, Campbell HF, Klein S, Airey JE, Darkes P, Powers M, Schnapper M, Neuenschwander K, Fitzpatrick LR, Pendley CE, et al. Youssefyeh RD, et al. J Med Chem. 1992 Mar 6;35(5):895-903. doi: 10.1021/jm00083a014. J Med Chem. 1992. PMID: 1312602

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