Klein K - Search Results

1

Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.

Khor CC, Winter S, Sutiman N, Mürdter TE, Chen S, Lim JSL, Li Z, Li J, Sim KS, Ganchev B, Eccles D, Eccles B, Tapper W, Zgheib NK, Tfayli A, Ng RCH, Yap YS, Lim E, Wong M, Wong NS, Ang PCS, Dent R, Tremmel R, Klein K, Schaeffeler E, Zhou Y, Lauschke VM, Eichelbaum M, Schwab M, Brauch HB, Chowbay B, Schroth W. Khor CC, et al. Among authors: klein k. Clin Pharmacol Ther. 2023 Mar;113(3):712-723. doi: 10.1002/cpt.2846. Epub 2023 Jan 31. Clin Pharmacol Ther. 2023. PMID: 36629403

2

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Lang T, Klein K, Fischer J, Nüssler AK, Neuhaus P, Hofmann U, Eichelbaum M, Schwab M, Zanger UM. Lang T, et al. Among authors: klein k. Pharmacogenetics. 2001 Jul;11(5):399-415. doi: 10.1097/00008571-200107000-00004. Pharmacogenetics. 2001. PMID: 11470993

3

Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction.

Endrizzi K, Fischer J, Klein K, Schwab M, Nüssler A, Neuhaus P, Eichelbaum M, Zanger UM. Endrizzi K, et al. Among authors: klein k. Anal Biochem. 2002 Jan 15;300(2):121-31. doi: 10.1006/abio.2001.5453. Anal Biochem. 2002. PMID: 11779102

4

Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation.

Bredschneider M, Klein K, Mürdter TE, Marx C, Eichelbaum M, Nüssler AK, Neuhaus P, Zanger UM, Schwab M. Bredschneider M, et al. Among authors: klein k. Clin Pharmacol Ther. 2002 Jun;71(6):479-87. doi: 10.1067/mcp.2002.124518. Clin Pharmacol Ther. 2002. PMID: 12087351

5

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

Coller JK, Krebsfaenger N, Klein K, Endrizzi K, Wolbold R, Lang T, Nüssler A, Neuhaus P, Zanger UM, Eichelbaum M, Mürdter TE. Coller JK, et al. Among authors: klein k. Br J Clin Pharmacol. 2002 Aug;54(2):157-67. doi: 10.1046/j.1365-2125.2002.01614.x. Br J Clin Pharmacol. 2002. PMID: 12207635 Free PMC article.

6

Sex is a major determinant of CYP3A4 expression in human liver.

Wolbold R, Klein K, Burk O, Nüssler AK, Neuhaus P, Eichelbaum M, Schwab M, Zanger UM. Wolbold R, et al. Among authors: klein k. Hepatology. 2003 Oct;38(4):978-88. doi: 10.1053/jhep.2003.50393. Hepatology. 2003. PMID: 14512885

7

Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity.

Coller JK, Krebsfaenger N, Klein K, Wolbold R, Nüssler A, Neuhaus P, Zanger UM, Eichelbaum M, Mürdter TE. Coller JK, et al. Among authors: klein k. Br J Clin Pharmacol. 2004 Jan;57(1):105-11. doi: 10.1046/j.1365-2125.2003.01970.x. Br J Clin Pharmacol. 2004. PMID: 14678348 Free PMC article.

8

Multiple novel nonsynonymous CYP2B6 gene polymorphisms in Caucasians: demonstration of phenotypic null alleles.

Lang T, Klein K, Richter T, Zibat A, Kerb R, Eichelbaum M, Schwab M, Zanger UM. Lang T, et al. Among authors: klein k. J Pharmacol Exp Ther. 2004 Oct;311(1):34-43. doi: 10.1124/jpet.104.068973. Epub 2004 Jun 9. J Pharmacol Exp Ther. 2004. PMID: 15190123

9

A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.

Raimundo S, Toscano C, Klein K, Fischer J, Griese EU, Eichelbaum M, Schwab M, Zanger UM. Raimundo S, et al. Among authors: klein k. Clin Pharmacol Ther. 2004 Aug;76(2):128-38. doi: 10.1016/j.clpt.2004.04.009. Clin Pharmacol Ther. 2004. PMID: 15289790

10

A natural CYP2B6 TATA box polymorphism (-82T--> C) leading to enhanced transcription and relocation of the transcriptional start site.

Zukunft J, Lang T, Richter T, Hirsch-Ernst KI, Nussler AK, Klein K, Schwab M, Eichelbaum M, Zanger UM. Zukunft J, et al. Among authors: klein k. Mol Pharmacol. 2005 May;67(5):1772-82. doi: 10.1124/mol.104.008086. Epub 2005 Feb 18. Mol Pharmacol. 2005. PMID: 15722458

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