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Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.
Klück V, van Deuren RC, Cavalli G, Shaukat A, Arts P, Cleophas MC, Crișan TO, Tausche AK, Riches P, Dalbeth N, Stamp LK, Hindmarsh JH, Jansen TLTA, Janssen M, Steehouwer M, Lelieveld S, van de Vorst M, Gilissen C, Dagna L, Van de Veerdonk FL, Eisenmesser EZ, Kim S, Merriman TR, Hoischen A, Netea MG, Dinarello CA, Joosten LA. Klück V, et al. Ann Rheum Dis. 2020 Apr;79(4):536-544. doi: 10.1136/annrheumdis-2019-216233. Epub 2020 Feb 29. Ann Rheum Dis. 2020. PMID: 32114511
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial.
Klück V, Jansen TLTA, Janssen M, Comarniceanu A, Efdé M, Tengesdal IW, Schraa K, Cleophas MCP, Scribner CL, Skouras DB, Marchetti C, Dinarello CA, Joosten LAB. Klück V, et al. Lancet Rheumatol. 2020 May;2(5):e270-e280. doi: 10.1016/s2665-9913(20)30065-5. Epub 2020 Apr 8. Lancet Rheumatol. 2020. PMID: 33005902 Free PMC article.
In vitro induction of trained immunity in adherent human monocytes.
Domínguez-Andrés J, Arts RJW, Bekkering S, Bahrar H, Blok BA, de Bree LCJ, Bruno M, Bulut Ö, Debisarun PA, Dijkstra H, Cristina Dos Santos J, Ferreira AV, Flores-Gomez D, Groh LA, Grondman I, Helder L, Jacobs C, Jacobs L, Jansen T, Kilic G, Klück V, Koeken VACM, Lemmers H, Moorlag SJCFM, Mourits VP, van Puffelen JH, Rabold K, Röring RJ, Rosati D, Tercan H, van Tuijl J, Quintin J, van Crevel R, Riksen NP, Joosten LAB, Netea MG. Domínguez-Andrés J, et al. Among authors: kluck v. STAR Protoc. 2021 Feb 24;2(1):100365. doi: 10.1016/j.xpro.2021.100365. eCollection 2021 Mar 19. STAR Protoc. 2021. PMID: 33718890 Free PMC article.
Urate-induced epigenetic modifications in myeloid cells.
Badii M, Gaal OI, Cleophas MC, Klück V, Davar R, Habibi E, Keating ST, Novakovic B, Helsen MM, Dalbeth N, Stamp LK, Macartney-Coxson D, Phipps-Green AJ, Stunnenberg HG, Dinarello CA, Merriman TR, Netea MG, Crişan TO, Joosten LAB. Badii M, et al. Among authors: kluck v. Arthritis Res Ther. 2021 Jul 28;23(1):202. doi: 10.1186/s13075-021-02580-1. Arthritis Res Ther. 2021. PMID: 34321071 Free PMC article.
A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis.
Klück V, Boahen CK, Kischkel B, Dos Santos JC, Matzaraki V, Boer CG, van Meurs JBJ; Genetics of Osteoarthritis (GO) consortium; Schraa K, Lemmers H, Dijkstra H, Leask MP, Merriman TR, Crişan TO, McCarthy GM, Kumar V, Joosten LAB. Klück V, et al. Osteoarthritis Cartilage. 2023 Aug;31(8):1022-1034. doi: 10.1016/j.joca.2023.04.011. Epub 2023 Apr 25. Osteoarthritis Cartilage. 2023. PMID: 37105395 Free article.
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