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The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders.
Witkin JM, Lippa A, Smith JL, Jin X, Ping X, Biggerstaff A, Kivell BM, Knutson DE, Sharmin D, Pandey KP, Mian MY, Cook JM, Cerne R. Witkin JM, et al. Among authors: kivell bm. Pharmacol Biochem Behav. 2022 Feb;213:173321. doi: 10.1016/j.pbb.2021.173321. Epub 2022 Jan 15. Pharmacol Biochem Behav. 2022. PMID: 35041859 Review.
The α2,3-selective potentiators of GABAA receptors, KRM-II-81 and MP-III-80, produce anxiolytic-like effects and block chemotherapy-induced hyperalgesia in mice without tolerance development.
Biggerstaff A, Kivell B, Smith JL, Mian MY, Golani LK, Rashid F, Sharmin D, Knutson DE, Cerne R, Cook JM, Witkin JM. Biggerstaff A, et al. Pharmacol Biochem Behav. 2020 Sep;196:172996. doi: 10.1016/j.pbb.2020.172996. Epub 2020 Jul 12. Pharmacol Biochem Behav. 2020. PMID: 32668266
52 results