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Senolytics reduce coronavirus-related mortality in old mice.
Camell CD, Yousefzadeh MJ, Zhu Y, Prata LGPL, Huggins MA, Pierson M, Zhang L, O'Kelly RD, Pirtskhalava T, Xun P, Ejima K, Xue A, Tripathi U, Espindola-Netto JM, Giorgadze N, Atkinson EJ, Inman CL, Johnson KO, Cholensky SH, Carlson TW, LeBrasseur NK, Khosla S, O'Sullivan MG, Allison DB, Jameson SC, Meves A, Li M, Prakash YS, Chiarella SE, Hamilton SE, Tchkonia T, Niedernhofer LJ, Kirkland JL, Robbins PD. Camell CD, et al. Among authors: kirkland jl. Science. 2021 Jul 16;373(6552):eabe4832. doi: 10.1126/science.abe4832. Epub 2021 Jun 8. Science. 2021. PMID: 34103349 Free PMC article.
Adipogenesis and aging: does aging make fat go MAD?
Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Kirkland JL, et al. Exp Gerontol. 2002 Jun;37(6):757-67. doi: 10.1016/s0531-5565(02)00014-1. Exp Gerontol. 2002. PMID: 12175476 Review.
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.
Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Guo W, et al. Among authors: kirkland jl. Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. doi: 10.1152/ajpendo.00557.2006. Epub 2006 Dec 5. Am J Physiol Endocrinol Metab. 2007. PMID: 17148751 Free article.
Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.
Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL. Tchkonia T, et al. Among authors: kirkland jl. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1810-9. doi: 10.1152/ajpendo.00295.2007. Epub 2007 Oct 2. Am J Physiol Endocrinol Metab. 2007. PMID: 17911345 Free article.
Sex- and depot-dependent differences in adipogenesis in normal-weight humans.
Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD. Tchoukalova YD, et al. Among authors: kirkland jl. Obesity (Silver Spring). 2010 Oct;18(10):1875-80. doi: 10.1038/oby.2010.56. Epub 2010 Mar 18. Obesity (Silver Spring). 2010. PMID: 20300084 Free PMC article.
Fat tissue, aging, and cellular senescence.
Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: kirkland jl. Aging Cell. 2010 Oct;9(5):667-84. doi: 10.1111/j.1474-9726.2010.00608.x. Epub 2010 Aug 15. Aging Cell. 2010. PMID: 20701600 Free PMC article. Review.
353 results