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A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
Yang AC, Vest RT, Kern F, Lee DP, Agam M, Maat CA, Losada PM, Chen MB, Schaum N, Khoury N, Toland A, Calcuttawala K, Shin H, Pálovics R, Shin A, Wang EY, Luo J, Gate D, Schulz-Schaeffer WJ, Chu P, Siegenthaler JA, McNerney MW, Keller A, Wyss-Coray T. Yang AC, et al. Among authors: khoury n. Nature. 2022 Mar;603(7903):885-892. doi: 10.1038/s41586-021-04369-3. Epub 2022 Feb 14. Nature. 2022. PMID: 35165441 Free PMC article.
Ageing hallmarks exhibit organ-specific temporal signatures.
Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium; Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T. Schaum N, et al. Nature. 2020 Jul;583(7817):596-602. doi: 10.1038/s41586-020-2499-y. Epub 2020 Jul 15. Nature. 2020. PMID: 32669715 Free PMC article.
Exercise plasma boosts memory and dampens brain inflammation via clusterin.
De Miguel Z, Khoury N, Betley MJ, Lehallier B, Willoughby D, Olsson N, Yang AC, Hahn O, Lu N, Vest RT, Bonanno LN, Yerra L, Zhang L, Saw NL, Fairchild JK, Lee D, Zhang H, McAlpine PL, Contrepois K, Shamloo M, Elias JE, Rando TA, Wyss-Coray T. De Miguel Z, et al. Among authors: khoury n. Nature. 2021 Dec;600(7889):494-499. doi: 10.1038/s41586-021-04183-x. Epub 2021 Dec 8. Nature. 2021. PMID: 34880498 Free PMC article.
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium; Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T. Pálovics R, et al. Nature. 2022 Mar;603(7900):309-314. doi: 10.1038/s41586-022-04461-2. Epub 2022 Mar 2. Nature. 2022. PMID: 35236985 Free PMC article.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, Chau R, Yulyaningsih E, Lopez I, Solanoy H, Masoud ST, Liang CC, Lin K, Astarita G, Khoury N, Zuchero JY, Thorne RG, Shen K, Miller S, Palop JJ, Garceau D, Sasner M, Whitesell JD, Harris JA, Hummel S, Gnörich J, Wind K, Kunze L, Zatcepin A, Brendel M, Willem M, Haass C, Barnett D, Zimmer TS, Orr AG, Scearce-Levie K, Lewcock JW, Di Paolo G, Sanchez PE. Xia D, et al. Among authors: khoury n. Mol Neurodegener. 2022 Jun 11;17(1):41. doi: 10.1186/s13024-022-00547-7. Mol Neurodegener. 2022. PMID: 35690868 Free PMC article.
A novel knockout mouse model of the noncoding antisense Brain-Derived Neurotrophic Factor (Bdnf) gene displays increased endogenous Bdnf protein and improved memory function following exercise.
Modarresi F, Pedram Fatemi R, Razavipour SF, Ricciardi N, Makhmutova M, Khoury N, Magistri M, Volmar CH, Wahlestedt C, Faghihi MA. Modarresi F, et al. Among authors: khoury n. Heliyon. 2021 Jul 15;7(7):e07570. doi: 10.1016/j.heliyon.2021.e07570. eCollection 2021 Jul. Heliyon. 2021. PMID: 34377851 Free PMC article.
310 results