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Computational optimization of antibody humanness and stability by systematic energy-based ranking.
Tennenhouse A, Khmelnitsky L, Khalaila R, Yeshaya N, Noronha A, Lindzen M, Makowski EK, Zaretsky I, Sirkis YF, Galon-Wolfenson Y, Tessier PM, Abramson J, Yarden Y, Fass D, Fleishman SJ. Tennenhouse A, et al. Among authors: khmelnitsky l. Nat Biomed Eng. 2024 Jan;8(1):30-44. doi: 10.1038/s41551-023-01079-1. Epub 2023 Aug 7. Nat Biomed Eng. 2024. PMID: 37550425
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ. Warszawski S, et al. Among authors: khmelnitsky l. PLoS Comput Biol. 2019 Aug 23;15(8):e1007207. doi: 10.1371/journal.pcbi.1007207. eCollection 2019 Aug. PLoS Comput Biol. 2019. PMID: 31442220 Free PMC article.
Diversity of CysD domains in gel-forming mucins.
Khmelnitsky L, Milo A, Dym O, Fass D. Khmelnitsky L, et al. FEBS J. 2023 Nov;290(21):5196-5203. doi: 10.1111/febs.16918. Epub 2023 Aug 11. FEBS J. 2023. PMID: 37526947
Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Javitt G, Khmelnitsky L, Albert L, Bigman LS, Elad N, Morgenstern D, Ilani T, Levy Y, Diskin R, Fass D. Javitt G, et al. Among authors: khmelnitsky l. Cell. 2020 Oct 29;183(3):717-729.e16. doi: 10.1016/j.cell.2020.09.021. Epub 2020 Oct 7. Cell. 2020. PMID: 33031746 Free PMC article.
Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ. Warszawski S, et al. Among authors: khmelnitsky l. PLoS Comput Biol. 2020 Oct 21;16(10):e1008382. doi: 10.1371/journal.pcbi.1008382. eCollection 2020 Oct. PLoS Comput Biol. 2020. PMID: 33085658 Free PMC article.