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Computational optimization of antibody humanness and stability by systematic energy-based ranking.
Nat Biomed Eng. 2024 Jan;8(1):30-44. doi: 10.1038/s41551-023-01079-1. Epub 2023 Aug 7.
Nat Biomed Eng. 2024.
PMID: 37550425
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ.
Warszawski S, et al. Among authors: khmelnitsky l.
PLoS Comput Biol. 2019 Aug 23;15(8):e1007207. doi: 10.1371/journal.pcbi.1007207. eCollection 2019 Aug.
PLoS Comput Biol. 2019.
PMID: 31442220
Free PMC article.
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Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion.
Javitt G, Yeshaya N, Khmelnitsky L, Fass D.
Javitt G, et al. Among authors: khmelnitsky l.
Blood. 2022 Dec 29;140(26):2835-2843. doi: 10.1182/blood.2022017153.
Blood. 2022.
PMID: 36179246
Free PMC article.
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Diversity of CysD domains in gel-forming mucins.
Khmelnitsky L, Milo A, Dym O, Fass D.
Khmelnitsky L, et al.
FEBS J. 2023 Nov;290(21):5196-5203. doi: 10.1111/febs.16918. Epub 2023 Aug 11.
FEBS J. 2023.
PMID: 37526947
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Assembly Mechanism of Mucin and von Willebrand Factor Polymers.
Javitt G, Khmelnitsky L, Albert L, Bigman LS, Elad N, Morgenstern D, Ilani T, Levy Y, Diskin R, Fass D.
Javitt G, et al. Among authors: khmelnitsky l.
Cell. 2020 Oct 29;183(3):717-729.e16. doi: 10.1016/j.cell.2020.09.021. Epub 2020 Oct 7.
Cell. 2020.
PMID: 33031746
Free PMC article.
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Correction: Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces.
Warszawski S, Borenstein Katz A, Lipsh R, Khmelnitsky L, Ben Nissan G, Javitt G, Dym O, Unger T, Knop O, Albeck S, Diskin R, Fass D, Sharon M, Fleishman SJ.
Warszawski S, et al. Among authors: khmelnitsky l.
PLoS Comput Biol. 2020 Oct 21;16(10):e1008382. doi: 10.1371/journal.pcbi.1008382. eCollection 2020 Oct.
PLoS Comput Biol. 2020.
PMID: 33085658
Free PMC article.
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