Kharel P - Search Results

1

Isolation and initial structure-functional characterization of endogenous tRNA-derived stress-induced RNAs.

Akiyama Y, Kharel P, Abe T, Anderson P, Ivanov P. Akiyama Y, et al. Among authors: kharel p. RNA Biol. 2020 Aug;17(8):1116-1124. doi: 10.1080/15476286.2020.1732702. Epub 2020 Mar 1. RNA Biol. 2020. PMID: 32116132 Free PMC article.

2

eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function.

Lyons SM, Kharel P, Akiyama Y, Ojha S, Dave D, Tsvetkov V, Merrick W, Ivanov P, Anderson P. Lyons SM, et al. Among authors: kharel p. Nucleic Acids Res. 2020 Jun 19;48(11):6223-6233. doi: 10.1093/nar/gkaa336. Nucleic Acids Res. 2020. PMID: 32374873 Free PMC article.

3

Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back.

Kharel P, Becker G, Tsvetkov V, Ivanov P. Kharel P, et al. Nucleic Acids Res. 2020 Dec 16;48(22):12534-12555. doi: 10.1093/nar/gkaa1126. Nucleic Acids Res. 2020. PMID: 33264409 Free PMC article.

4

Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus.

Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, Ito H, Alayo QA, Kharel P, Giantini Larsen A, Fan WY, Auduong S, Grauwet K, Passaro C, Khalsa JK, Shah K, Reardon DA, Ligon KL, Beroukhim R, Nakashima H, Ivanov P, Anderson PJ, Lawler SE, Chiocca EA. Mineo M, et al. Among authors: kharel p. Mol Cell. 2020 Jun 18;78(6):1207-1223.e8. doi: 10.1016/j.molcel.2020.05.015. Epub 2020 Jun 5. Mol Cell. 2020. PMID: 32504554 Free PMC article.

5

The role of RNA G-quadruplexes in human diseases and therapeutic strategies.

Kharel P, Balaratnam S, Beals N, Basu S. Kharel P, et al. Wiley Interdiscip Rev RNA. 2020 Jan;11(1):e1568. doi: 10.1002/wrna.1568. Epub 2019 Sep 12. Wiley Interdiscip Rev RNA. 2020. PMID: 31514263 Review.

6

Rationally designed DNA therapeutics can modulate human TH expression by controlling specific GQ formation in its promoter.

Beals N, Farhath MM, Kharel P, Croos B, Mahendran T, Johnson J, Basu S. Beals N, et al. Among authors: kharel p. Mol Ther. 2022 Feb 2;30(2):831-844. doi: 10.1016/j.ymthe.2021.05.013. Epub 2021 May 14. Mol Ther. 2022. PMID: 33992806 Free PMC article.

7

Engineered domain swapping indicates context dependent functional role of RNA G-quadruplexes.

Bhattacharyya D, Morris MJ, Kharel P, Mirihana Arachchilage G, Fedeli KM, Basu S. Bhattacharyya D, et al. Among authors: kharel p. Biochimie. 2017 Jun;137:147-150. doi: 10.1016/j.biochi.2017.03.007. Epub 2017 Mar 16. Biochimie. 2017. PMID: 28322930

8

Targeting of G-Quadruplex Harboring Pre-miRNA 92b by LNA Rescues PTEN Expression in NSCL Cancer Cells.

Mirihana Arachchilage G, Kharel P, Reid J, Basu S. Mirihana Arachchilage G, et al. Among authors: kharel p. ACS Chem Biol. 2018 Apr 20;13(4):909-914. doi: 10.1021/acschembio.7b00749. Epub 2018 Mar 19. ACS Chem Biol. 2018. PMID: 29529863

9

Evidence of extensive RNA oxidation in normal appearing cortex of multiple sclerosis brain.

Kharel P, McDonough J, Basu S. Kharel P, et al. Neurochem Int. 2016 Jan;92:43-8. doi: 10.1016/j.neuint.2015.12.002. Epub 2015 Dec 17. Neurochem Int. 2016. PMID: 26706235

10

Mono- and bilayer smectic liquid crystal ordering in dense solutions of "gapped" DNA duplexes.

Gyawali P, Saha R, Smith GP, Salamonczyk M, Kharel P, Basu S, Li R, Fukuto M, Gleeson JT, Clark NA, Jákli A, Balci H, Sprunt S. Gyawali P, et al. Among authors: kharel p. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2019996118. doi: 10.1073/pnas.2019996118. Proc Natl Acad Sci U S A. 2021. PMID: 33731478 Free PMC article.

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