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Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans.
Matthaei J, Bonat WH, Kerb R, Tzvetkov MV, Strube J, Brunke S, Sachse-Seeboth C, Sehrt D, Hofmann U, von Bornemann Hjelmborg J, Schwab M, Brockmöller J. Matthaei J, et al. Among authors: kerb r. Front Genet. 2020 Aug 21;11:944. doi: 10.3389/fgene.2020.00944. eCollection 2020. Front Genet. 2020. PMID: 32973880 Free PMC article.
Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters.
Matthaei J, Tzvetkov MV, Gal V, Sachse-Seeboth C, Sehrt D, Hjelmborg JB, Hofmann U, Schwab M, Kerb R, Brockmöller J. Matthaei J, et al. Among authors: kerb r. Genome Med. 2016 Nov 8;8(1):119. doi: 10.1186/s13073-016-0372-2. Genome Med. 2016. PMID: 27825374 Free PMC article. Clinical Trial.
Heritability of metoprolol and torsemide pharmacokinetics.
Matthaei J, Brockmöller J, Tzvetkov MV, Sehrt D, Sachse-Seeboth C, Hjelmborg JB, Möller S, Halekoh U, Hofmann U, Schwab M, Kerb R. Matthaei J, et al. Among authors: kerb r. Clin Pharmacol Ther. 2015 Dec;98(6):611-21. doi: 10.1002/cpt.258. Epub 2015 Oct 19. Clin Pharmacol Ther. 2015. PMID: 26344676 Clinical Trial.
Data-driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment.
Fendt R, Hofmann U, Schneider ARP, Schaeffeler E, Burghaus R, Yilmaz A, Blank LM, Kerb R, Lippert J, Schlender JF, Schwab M, Kuepfer L. Fendt R, et al. Among authors: kerb r. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):782-793. doi: 10.1002/psp4.12646. Epub 2021 Jun 26. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34053199 Free PMC article. Clinical Trial.
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.
Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, Brosch M, von Schoenfels W, Erhart W, Schuppert A, Block M, Schaeffeler E, Boehmer G, Goerlitz L, Hoecker J, Lippert J, Kerb R, Hampe J, Kuepfer L, Schwab M. Krauss M, et al. Among authors: kerb r. NPJ Syst Biol Appl. 2017 Mar 28;3:11. doi: 10.1038/s41540-017-0012-5. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28649438 Free PMC article.
Simultaneous quantification of mefloquine (+)- and (-)-enantiomers and the carboxy metabolite in dried blood spots by liquid chromatography/tandem mass spectrometry.
Geditz MC, Lindner W, Lämmerhofer M, Heinkele G, Kerb R, Ramharter M, Schwab M, Hofmann U. Geditz MC, et al. Among authors: kerb r. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 1;968:32-9. doi: 10.1016/j.jchromb.2013.11.035. Epub 2013 Nov 25. J Chromatogr B Analyt Technol Biomed Life Sci. 2014. PMID: 24315337
66 results