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Randomized, double-blind, placebo-controlled, dose-escalating phase I, healthy subjects study of intravenous OPN-305, a humanized anti-TLR2 antibody.
Reilly M, Miller RM, Thomson MH, Patris V, Ryle P, McLoughlin L, Mutch P, Gilboy P, Miller C, Broekema M, Keogh B, McCormack W, van de Wetering de Rooij J. Reilly M, et al. Among authors: keogh b. Clin Pharmacol Ther. 2013 Nov;94(5):593-600. doi: 10.1038/clpt.2013.150. Epub 2013 Jul 23. Clin Pharmacol Ther. 2013. PMID: 23880971 Free PMC article. Clinical Trial.
Azo-reductase activated budesodine prodrugs for colon targeting.
Marquez Ruiz JF, Kedziora K, O'Reilly M, Maguire J, Keogh B, Windle H, Kelleher DP, Gilmer JF. Marquez Ruiz JF, et al. Among authors: keogh b. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7573-7. doi: 10.1016/j.bmcl.2012.10.006. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23122819
Lipoprotein(a) and treatment of chronic renal disease.
Buggy D, Breathnach A, Keogh B, Cooke T, Feely J. Buggy D, et al. Among authors: keogh b. J Intern Med. 1993 Nov;234(5):453-5. doi: 10.1111/j.1365-2796.1993.tb00777.x. J Intern Med. 1993. PMID: 8228788
Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs.
Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP. Arslan F, et al. Among authors: keogh b. Circ Cardiovasc Interv. 2012 Apr;5(2):279-87. doi: 10.1161/CIRCINTERVENTIONS.111.967596. Epub 2012 Feb 21. Circ Cardiovasc Interv. 2012. PMID: 22354933
382 results