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Alpha-Ketoglutarate dietary supplementation to improve health in humans.
Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BK. Gyanwali B, et al. Among authors: kennedy bk. Trends Endocrinol Metab. 2022 Feb;33(2):136-146. doi: 10.1016/j.tem.2021.11.003. Epub 2021 Dec 21. Trends Endocrinol Metab. 2022. PMID: 34952764 Review.
Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.
Cohen AA, Kennedy BK, Anglas U, Bronikowski AM, Deelen J, Dufour F, Ferbeyre G, Ferrucci L, Franceschi C, Frasca D, Friguet B, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Gut P, Ivanchenko M, Legault V, Lemaître JF, Liontis T, Liu GH, Liu M, Maier AB, Nóbrega OT, Olde Rikkert MGM, Pawelec G, Rheault S, Senior AM, Simm A, Soo S, Traa A, Ukraintseva S, Vanhaelen Q, Van Raamsdonk JM, Witkowski JM, Yashin AI, Ziman R, Fülöp T. Cohen AA, et al. Among authors: kennedy bk. Mech Ageing Dev. 2020 Oct;191:111316. doi: 10.1016/j.mad.2020.111316. Epub 2020 Jul 18. Mech Ageing Dev. 2020. PMID: 32693105 Free PMC article.
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.
Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Asadi Shahmirzadi A, et al. Among authors: kennedy bk. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. Cell Metab. 2020. PMID: 32877690 Free PMC article.
The conundrum of human immune system "senescence".
Pawelec G, Bronikowski A, Cunnane SC, Ferrucci L, Franceschi C, Fülöp T, Gaudreau P, Gladyshev VN, Gonos ES, Gorbunova V, Kennedy BK, Larbi A, Lemaître JF, Liu GH, Maier AB, Morais JA, Nóbrega OT, Moskalev A, Rikkert MO, Seluanov A, Senior AM, Ukraintseva S, Vanhaelen Q, Witkowski J, Cohen AA. Pawelec G, et al. Among authors: kennedy bk. Mech Ageing Dev. 2020 Dec;192:111357. doi: 10.1016/j.mad.2020.111357. Epub 2020 Sep 17. Mech Ageing Dev. 2020. PMID: 32949594 Free PMC article. Review.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test.
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV. Demidenko O, et al. Among authors: kennedy bk. Aging (Albany NY). 2021 Nov 30;13(22):24485-24499. doi: 10.18632/aging.203736. Epub 2021 Nov 30. Aging (Albany NY). 2021. PMID: 34847066 Free PMC article.
Targeting aging mechanisms: pharmacological perspectives.
Moskalev A, Guvatova Z, Lopes IA, Beckett CW, Kennedy BK, De Magalhaes JP, Makarov AA. Moskalev A, et al. Among authors: kennedy bk. Trends Endocrinol Metab. 2022 Apr;33(4):266-280. doi: 10.1016/j.tem.2022.01.007. Epub 2022 Feb 17. Trends Endocrinol Metab. 2022. PMID: 35183431 Review.
238 results