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Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Martínez-López M, Iborra S, Conde-Garrosa R, Mastrangelo A, Danne C, Mann ER, Reid DM, Gaboriau-Routhiau V, Chaparro M, Lorenzo MP, Minnerup L, Saz-Leal P, Slack E, Kemp B, Gisbert JP, Dzionek A, Robinson MJ, Rupérez FJ, Cerf-Bensussan N, Brown GD, Bernardo D, LeibundGut-Landmann S, Sancho D. Martínez-López M, et al. Among authors: kemp b. Immunity. 2019 Feb 19;50(2):446-461.e9. doi: 10.1016/j.immuni.2018.12.020. Epub 2019 Jan 29. Immunity. 2019. PMID: 30709742 Free PMC article.
Leishmania Uses Mincle to Target an Inhibitory ITAM Signaling Pathway in Dendritic Cells that Dampens Adaptive Immunity to Infection.
Iborra S, Martínez-López M, Cueto FJ, Conde-Garrosa R, Del Fresno C, Izquierdo HM, Abram CL, Mori D, Campos-Martín Y, Reguera RM, Kemp B, Yamasaki S, Robinson MJ, Soto M, Lowell CA, Sancho D. Iborra S, et al. Among authors: kemp b. Immunity. 2016 Oct 18;45(4):788-801. doi: 10.1016/j.immuni.2016.09.012. Epub 2016 Oct 11. Immunity. 2016. PMID: 27742545 Free PMC article.
Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags".
Percival-Alwyn JL, England E, Kemp B, Rapley L, Davis NH, McCarthy GR, Majithiya JB, Corkill DJ, Welsted S, Minton K, Cohen ES, Robinson MJ, Dobson C, Wilkinson TC, Vaughan TJ, Groves MA, Tigue NJ. Percival-Alwyn JL, et al. Among authors: kemp b. MAbs. 2015;7(1):129-37. doi: 10.4161/19420862.2014.985489. MAbs. 2015. PMID: 25523454 Free PMC article.
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation.
Cohen ES, Scott IC, Majithiya JB, Rapley L, Kemp BP, England E, Rees DG, Overed-Sayer CL, Woods J, Bond NJ, Veyssier CS, Embrey KJ, Sims DA, Snaith MR, Vousden KA, Strain MD, Chan DT, Carmen S, Huntington CE, Flavell L, Xu J, Popovic B, Brightling CE, Vaughan TJ, Butler R, Lowe DC, Higazi DR, Corkill DJ, May RD, Sleeman MA, Mustelin T. Cohen ES, et al. Among authors: kemp bp. Nat Commun. 2015 Sep 14;6:8327. doi: 10.1038/ncomms9327. Nat Commun. 2015. PMID: 26365875 Free PMC article.
Engineering the expression of an anti-interleukin-13 antibody through rational design and mutagenesis.
Popovic B, Gibson S, Senussi T, Carmen S, Kidd S, Slidel T, Strickland I, Jianqing X, Spooner J, Lewis A, Hudson N, Mackenzie L, Keen J, Kemp B, Hardman C, Hatton D, Wilkinson T, Vaughan T, Lowe D. Popovic B, et al. Among authors: kemp b. Protein Eng Des Sel. 2017 Apr 1;30(4):303-311. doi: 10.1093/protein/gzx001. Protein Eng Des Sel. 2017. PMID: 28130326
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.
England E, Rees DG, Scott IC, Carmen S, Chan DTY, Chaillan Huntington CE, Houslay KF, Erngren T, Penney M, Majithiya JB, Rapley L, Sims DA, Hollins C, Hinchy EC, Strain MD, Kemp BP, Corkill DJ, May RD, Vousden KA, Butler RJ, Mustelin T, Vaughan TJ, Lowe DC, Colley C, Cohen ES. England E, et al. Among authors: kemp bp. Sci Rep. 2023 Jun 17;13(1):9825. doi: 10.1038/s41598-023-36642-y. Sci Rep. 2023. PMID: 37330528 Free PMC article.
Evaluation of strategies to control Fab light chain dimer during mammalian expression and purification: A universal one-step process for purification of correctly assembled Fab.
Spooner J, Keen J, Nayyar K, Birkett N, Bond N, Bannister D, Tigue N, Higazi D, Kemp B, Vaughan T, Kippen A, Buchanan A. Spooner J, et al. Among authors: kemp b. Biotechnol Bioeng. 2015 Jul;112(7):1472-7. doi: 10.1002/bit.25550. Epub 2015 Mar 12. Biotechnol Bioeng. 2015. PMID: 25619171
Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.
Chen B, Vousden KA, Naiman B, Turman S, Sun H, Wang S, Vinall LMK, Kemp BP, Kasturiangan S, Rees DG, Grant E, Hinrichs MJ, Eck S, DiGiandomenico A, Jack Borrok M, Ly N, Xiong X, Gonzalez C, Morehouse C, Wang Y, Zhou Y, Cann J, Zhao W, Koelkebeck H, Okubo K, Mayadas TN, Howe D, Griffiths J, Kolbeck R, Herbst R, Sims GP. Chen B, et al. Among authors: kemp bp. Ann Rheum Dis. 2019 Feb;78(2):228-237. doi: 10.1136/annrheumdis-2018-213523. Epub 2018 Nov 20. Ann Rheum Dis. 2019. PMID: 30459279 Free PMC article.
Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13Rα1 and IL-13Rα2.
Popovic B, Breed J, Rees DG, Gardener MJ, Vinall LM, Kemp B, Spooner J, Keen J, Minter R, Uddin F, Colice G, Wilkinson T, Vaughan T, May RD. Popovic B, et al. Among authors: kemp b. J Mol Biol. 2017 Jan 20;429(2):208-219. doi: 10.1016/j.jmb.2016.12.005. Epub 2016 Dec 9. J Mol Biol. 2017. PMID: 27956146 Free article.
1,274 results