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IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model.
Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M, Bauer C. Lutz V, et al. Among authors: keber cu. Cancer Immunol Res. 2023 Apr 3;11(4):421-434. doi: 10.1158/2326-6066.CIR-22-0398. Cancer Immunol Res. 2023. PMID: 36758176
Selected commensals educate the intestinal vascular and immune system for immunocompetence.
Romero R, Zarzycka A, Preussner M, Fischer F, Hain T, Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U. Romero R, et al. Among authors: keber cu. Microbiome. 2022 Sep 28;10(1):158. doi: 10.1186/s40168-022-01353-5. Microbiome. 2022. PMID: 36171625 Free PMC article.
Dissecting the role of toll-like receptor 7 in pancreatic cancer.
Stark M, Nicolai M, Tatura M, Keber CU, Kaufmann A, Chung HR, Slater EP, Heeschen C, Lawlor RT, Scarpa A, Bartsch DK, Gress TM, Bauer S, Buchholz M. Stark M, et al. Among authors: keber cu. Cancer Med. 2023 Apr;12(7):8542-8556. doi: 10.1002/cam4.5606. Epub 2023 Jan 5. Cancer Med. 2023. PMID: 36602302 Free PMC article.
TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion.
Steitz AM, Schröder C, Knuth I, Keber CU, Sommerfeld L, Finkernagel F, Jansen JM, Wagner U, Müller-Brüsselbach S, Worzfeld T, Huber M, Beutgen VM, Graumann J, Pogge von Strandmann E, Müller R, Reinartz S. Steitz AM, et al. Among authors: keber cu. iScience. 2023 Nov 7;26(12):108401. doi: 10.1016/j.isci.2023.108401. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047087 Free PMC article.
Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells.
Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, Finkernagel F, Worzfeld T, Burchert A, Keber C, Nist A, Stiewe T, Reinartz S, Beutgen VM, Graumann J, Pauck K, Garn H, Gaida M, Müller R, Huber M. Neuhaus F, et al. Clin Transl Med. 2024 Apr;14(4):e1604. doi: 10.1002/ctm2.1604. Clin Transl Med. 2024. PMID: 38566518 Free PMC article.
Partial p53 reactivation is sufficient to induce cancer regression.
Klimovich B, Meyer L, Merle N, Neumann M, König AM, Ananikidis N, Keber CU, Elmshäuser S, Timofeev O, Stiewe T. Klimovich B, et al. Among authors: keber cu. J Exp Clin Cancer Res. 2022 Mar 2;41(1):80. doi: 10.1186/s13046-022-02269-6. J Exp Clin Cancer Res. 2022. PMID: 35232479 Free PMC article.
The Hygiene Hypothesis - Learning From but Not Living in the Past.
Pfefferle PI, Keber CU, Cohen RM, Garn H. Pfefferle PI, et al. Among authors: keber cu. Front Immunol. 2021 Mar 16;12:635935. doi: 10.3389/fimmu.2021.635935. eCollection 2021. Front Immunol. 2021. PMID: 33796103 Free PMC article. Review.
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